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Targeting Therapeutics to the Glomerulus With Nanoparticles

Zuckerman, Jonathan E. and Davis, Mark E. (2013) Targeting Therapeutics to the Glomerulus With Nanoparticles. Advances in Chronic Kidney Disease, 20 (6). pp. 500-507. ISSN 1548-5595. doi:10.1053/j.ackd.2013.06.003.

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Nanoparticles are an enabling technology for the creation of tissue-/cell-specific therapeutics that have been investigated extensively as targeted therapeutics for cancer. The kidney, specifically the glomerulus, is another accessible site for nanoparticle delivery that has been relatively overlooked as a target organ. Given the medical need for the development of more potent, kidney-targeted therapies, the use of nanoparticle-based therapeutics may be one such solution to this problem. Here, we review the literature on nanoparticle targeting of the glomerulus. Specifically, we provide a broad overview of nanoparticle-based therapeutics and how the unique structural characteristics of the glomerulus allow for selective, nanoparticle targeting of this area of the kidney. We then summarize literature examples of nanoparticle delivery to the glomerulus and elaborate on the appropriate nanoparticle design criteria for glomerular targeting. Finally, we discuss the behavior of nanoparticles in animal models of diseased glomeruli and review examples of nanoparticle therapeutic approaches that have shown promise in animal models of glomerulonephritic disease.

Item Type:Article
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Davis, Mark E.0000-0001-8294-1477
Additional Information:© 2013 National Kidney Foundation, Inc. Published by Elsevier Inc. This work benefited from the use of the Caltech Materials Science transmission electron microscope facility, which is partially supported by the Materials Research Science and Engineering Centers program of the National Science Foundation under award number DMR-0520565. This work was supported by National Cancer Institute grant CA151819 and Sanofi-Aventis.
Funding AgencyGrant Number
National Cancer InstituteCA151819
Subject Keywords:Nanoparticles; Kidney; Glomerulus; Drug targeting; Glomerulonephritis
Issue or Number:6
Record Number:CaltechAUTHORS:20131212-125225083
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Official Citation:Jonathan E. Zuckerman, Mark E. Davis, Targeting Therapeutics to the Glomerulus With Nanoparticles, Advances in Chronic Kidney Disease, Volume 20, Issue 6, November 2013, Pages 500-507, ISSN 1548-5595,
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:42989
Deposited By: Jason Perez
Deposited On:13 Dec 2013 06:18
Last Modified:10 Nov 2021 16:31

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