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The Establishment of Lysogenicity in Escherichia Coli

Lieb, Margaret (1953) The Establishment of Lysogenicity in Escherichia Coli. Journal of Bacteriology, 65 (6). pp. 642-651. ISSN 0021-9193. PMCID PMC169593.

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When a population of sensitive bacteria is exposed to infection by a temperate phage, a large number of cells are not lysed and give rise to colonies containing lysogenic cells. Some of the factors influencing the probability that an infected cell of Escherichia coli, strain K12S, will give a lysogenic response are reported here. In addition, the present study deals with the change of free phage particles into the intracellular prophage form which is transmitted to all cells in a lysogenic culture. Information was obtained on specific questions regarding the establishment of lysogenicity, as, for example: When is the decision as to the type of response, i.e., lytic or lysogenic, made by the infected cell? How much time is required for transformation (reduction) of the infecting phage into prophage and what changes take place in the host cell? Is the prophage a cytoplasmic constituent of the lysogenic cell or linked to the genetic mechanism?

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Additional Information:© 1953 American Society for Microbiology. Received for publication November 17, 1952. Aided by a fellowship from the National Foundation for Infantile Paralysis. The author wishes to express thanks to Dr. J. J. Weigle for his interest and help during the course of these investigations and also to Professors M. Delbrück and R. Dulbecco for their many valuable suggestions.
Funding AgencyGrant Number
National Foundation for Infantile ParalysisUNSPECIFIED
Issue or Number:6
PubMed Central ID:PMC169593
Record Number:CaltechAUTHORS:20131217-141305804
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Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:43050
Deposited By: Tony Diaz
Deposited On:23 Dec 2013 21:40
Last Modified:03 Oct 2019 06:04

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