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The Isolation of Myxomyosin, an ATP-Sensitive Protein from the Plasmodium of a Myxomycete

Ts'o, Paul O. P. and Eggman, Luther and Vinograd, Jerome (1956) The Isolation of Myxomyosin, an ATP-Sensitive Protein from the Plasmodium of a Myxomycete. Journal of General Physiology, 39 (5). pp. 801-812. ISSN 0022-1295. PMCID PMC2147562. doi:10.1085/jgp.39.5.801.

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1. A procedure has been developed for the preparation of an active concentrate from the myxomycete, Physarum polycephalum. This concentrate responds with a lowered viscosity to the addition of small amounts of ATP. The preparation recovers in viscosity, and the process may be repeated. 2. In the most active concentrates, 75 per cent of the non-dialyzable material moves as a single boundary both in the descending limb in electrophoresis and in the ultracentrifuge. It contains about 10 per cent ribonucleic acid, which is at least in part reversibly bound to the protein. 3. The active material has been designated myxomyosin because of its origin and its similarity to actomyosin in ATP response.

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Additional Information:© 1956 Rockefeller University Press. Received for publication, October 3, 1955. Report of work supported in part by a grant from the National Institutes of Health, United States Public Health Service.
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Caltech Gates and Crellin Laboratories of Chemistry2030
Issue or Number:5
PubMed Central ID:PMC2147562
Record Number:CaltechAUTHORS:20131218-095718870
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Official Citation:THE ISOLATION OF MYXOMYOSIN, AN ATP-SENSITIVE PROTEIN FROM THE PLASMODIUM OF A MYXOMYCETE Paul O. P. Ts'o, Luther Eggman, Jerome Vinograd The Journal of General Physiology May 1956, 39 (5) 801-812; DOI: 10.1085/jgp.39.5.801
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:43059
Deposited By: Tony Diaz
Deposited On:18 Dec 2013 21:31
Last Modified:10 Nov 2021 16:32

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