Hsieh-Wilson, Linda C. and Griffin, Matthew E. (2013) Improving Biologic Drugs via Total Chemical Synthesis. Science, 342 (6164). pp. 1332-1333. ISSN 0036-8075. doi:10.1126/science.1247615. https://resolver.caltech.edu/CaltechAUTHORS:20140102-144409776
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Abstract
Most biologic therapeutics are large, complex molecules or heterogeneous mixtures of molecules that are manufactured in a living system (e.g., microorganism, plant cell, or animal cell) through recombinant DNA technology. Biologics are now being used to treat a wide range of diseases, including cancer, autoimmune disorders, and diabetes. It is estimated that half of the top 100 best-selling medications will soon be biologics, with Roche's anticancer biologic Avastin and AbbVie's anti-inflammatory antibody Humira rivaling the success of Pfizer's small-molecule drug Lipitor (1). Biologics differ fundamentally from small-molecule drugs in terms of purity, composition, and production. Small-molecule drugs typically have homogeneous, well-defined structures that have been finely tuned with atomic-level precision via chemical synthesis. On page 1357 of this issue, Wang et al. (2) bridge the gap between biologics and small-molecule drugs by accomplishing the total chemical synthesis of the biologic erythropoietin (EPO) in a single, pure form.
| Item Type: | Article | |||||||||
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| Additional Information: | © 2013 American Association for the Advancement of Science. | |||||||||
| Issue or Number: | 6164 | |||||||||
| DOI: | 10.1126/science.1247615 | |||||||||
| Record Number: | CaltechAUTHORS:20140102-144409776 | |||||||||
| Persistent URL: | https://resolver.caltech.edu/CaltechAUTHORS:20140102-144409776 | |||||||||
| Official Citation: | Hsieh-Wilson, L. C., & Griffin, M. E. (2013). Improving Biologic Drugs via Total Chemical Synthesis. Science, 342(6164), 1332-1333. doi: 10.1126/science.1247615 | |||||||||
| Usage Policy: | No commercial reproduction, distribution, display or performance rights in this work are provided. | |||||||||
| ID Code: | 43182 | |||||||||
| Collection: | CaltechAUTHORS | |||||||||
| Deposited By: | Tony Diaz | |||||||||
| Deposited On: | 04 Jan 2014 00:07 | |||||||||
| Last Modified: | 10 Nov 2021 16:34 |
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