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Improving Biologic Drugs via Total Chemical Synthesis

Hsieh-Wilson, Linda C. and Griffin, Matthew E. (2013) Improving Biologic Drugs via Total Chemical Synthesis. Science, 342 (6164). pp. 1332-1333. ISSN 0036-8075. doi:10.1126/science.1247615. https://resolver.caltech.edu/CaltechAUTHORS:20140102-144409776

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Abstract

Most biologic therapeutics are large, complex molecules or heterogeneous mixtures of molecules that are manufactured in a living system (e.g., microorganism, plant cell, or animal cell) through recombinant DNA technology. Biologics are now being used to treat a wide range of diseases, including cancer, autoimmune disorders, and diabetes. It is estimated that half of the top 100 best-selling medications will soon be biologics, with Roche's anticancer biologic Avastin and AbbVie's anti-inflammatory antibody Humira rivaling the success of Pfizer's small-molecule drug Lipitor (1). Biologics differ fundamentally from small-molecule drugs in terms of purity, composition, and production. Small-molecule drugs typically have homogeneous, well-defined structures that have been finely tuned with atomic-level precision via chemical synthesis. On page 1357 of this issue, Wang et al. (2) bridge the gap between biologics and small-molecule drugs by accomplishing the total chemical synthesis of the biologic erythropoietin (EPO) in a single, pure form.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1126/science.1247615 DOIArticle
http://www.sciencemag.org/content/342/6164/1332PublisherArticle
ORCID:
AuthorORCID
Hsieh-Wilson, Linda C.0000-0001-5661-1714
Additional Information:© 2013 American Association for the Advancement of Science.
Issue or Number:6164
DOI:10.1126/science.1247615
Record Number:CaltechAUTHORS:20140102-144409776
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20140102-144409776
Official Citation:Hsieh-Wilson, L. C., & Griffin, M. E. (2013). Improving Biologic Drugs via Total Chemical Synthesis. Science, 342(6164), 1332-1333. doi: 10.1126/science.1247615
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:43182
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:04 Jan 2014 00:07
Last Modified:10 Nov 2021 16:34

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