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Characterizing white matter health and organization in atherosclerotic vascular disease: A diffusion tensor imaging study

Bijanki, Kelly Rowe and Arndt, Stephan and Magnotta, Vincent A. and Nopoulos, Peg and Paradiso, Sergio and Matsui, Joy T. and Johnson, Hans J. and Moser, David J. (2013) Characterizing white matter health and organization in atherosclerotic vascular disease: A diffusion tensor imaging study. Psychiatry Research: Neuroimanging, 214 (3). pp. 389-394. ISSN 0925-4927. doi:10.1016/j.pscychresns.2013.07.011.

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Atherosclerotic vascular disease (AVD) is endemic to the developed world, with known negative outcomes for cognition and brain health. The effects of AVD on the white matter fibers of the brain have not yet been studied using diffusion tensor imaging (DTI). This study examined differences in fractional anisotropy (FA) between AVD and healthy comparison (HC) participants, and described the regional patterns of FA in each group. AVD participants were hypothesized to have lower FA than HC participants, indicating abnormalities in white matter health or organization. 1.5 T diffusion tensor imaging was performed in 35 AVD and 22 HC participants. Mean FA measures were calculated for the white matter of the whole brain, as well for individual lobes. Globally and in every brain region measured except the temporal lobes, there were significant effects of group where AVD participants had lower FA values than their HC counterparts. Group differences in FA remained significant when controlled for white matter hyperintensity (WMH) volume, suggesting that FA detects white matter abnormality above and beyond what is measurable using the older WMH technique. These findings suggest a likely neural substrate underlying the changes in cognition and mood reported in atherosclerotic vascular disease patients.

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Additional Information:© 2013 Elsevier Ireland Ltd. Received 23 August 2012. Received in revised form 17 June 2013. Accepted 25 July 2013. The authors would like to acknowledge the participants in the Aging, Vascular Disease, and Cognition study, without whose contributions of energy and time, none of the current research would have been possible. Financial support for the current study was provided to Dr. David J. Moser by the National Institutes on Aging (Grant numbers: 1 K23 AG020649-01A1, RO1AG030417-01A2), as well as a grant from the National Center for Research Resources (Grant number: UL1RR024979) made to the University of Iowa.
Funding AgencyGrant Number
National Institute on Aging1 K23 AG020649-01A1
National Institute on AgingRO1AG030417-01A2
National Center for Research ResourcesUL1RR024979
Subject Keywords: Diffusion-weighted imaging; Atherosclerosis; Leukoaraiosis; MRI; White matter disease
Issue or Number:3
Record Number:CaltechAUTHORS:20140103-080627002
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Official Citation:Kelly Rowe Bijanki, Stephan Arndt, Vincent A. Magnotta, Peg Nopoulos, Sergio Paradiso, Joy T. Matsui, Hans J. Johnson, David J. Moser, Characterizing white matter health and organization in atherosclerotic vascular disease: A diffusion tensor imaging study, Psychiatry Research: Neuroimaging, Volume 214, Issue 3, 30 December 2013, Pages 389-394, ISSN 0925-4927, (
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:43191
Deposited By: Ruth Sustaita
Deposited On:03 Jan 2014 16:25
Last Modified:10 Nov 2021 16:34

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