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Epigenetic mechanisms and developmental choice hierarchies in T-lymphocyte development

Rothenberg, Ellen V. (2013) Epigenetic mechanisms and developmental choice hierarchies in T-lymphocyte development. Briefings in Functional Genomics, 12 (6). pp. 512-524. ISSN 2041-2649. PMCID PMC3838197. doi:10.1093/bfgp/elt027.

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Three interlocking problems in gene regulation are: how to explain genome-wide targeting of transcription factors in different cell types, how prior transcription factor action can establish an ‘epigenetic state’ that changes the options for future transcription factor action, and how directly a sequence of developmental decisions can be memorialized in a hierarchy of repression structures applied to key genes of the ‘paths not taken’. This review uses the finely staged process of T-cell lineage commitment as a test case in which to examine how changes in developmental status are reflected in changes in transcription factor expression, transcription factor binding distribution across genomic sites, and chromatin modification. These are evaluated in a framework of reciprocal effects of previous chromatin structure features on transcription factor access and of transcription factor binding on other factors and on future chromatin structure.

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URLURL TypeDescription DOIArticle CentralArticle
Rothenberg, Ellen V.0000-0002-3901-347X
Additional Information:© 2013 The Author. Published by Oxford University Press. First published online: August 6, 2013. I thank current and former members of my laboratory for stimulating discussions and for the chance to discuss our unpublished work. Funding: The US Public Health Service (National Institutes of Health grants RC2CA148248, R33HL089123, R01CA90233); the Albert Billings Ruddock Professorship of Biology.
Funding AgencyGrant Number
Albert Billings Ruddock Professorship of BiologyUNSPECIFIED
Subject Keywords:DNA binding; histone methylation; DNA methylation; lineage commitment; repression; hematopoiesis
Issue or Number:6
PubMed Central ID:PMC3838197
Record Number:CaltechAUTHORS:20140103-081036440
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Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:43192
Deposited By: Tony Diaz
Deposited On:03 Jan 2014 18:11
Last Modified:10 Nov 2021 16:34

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