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Co-translational protein targeting to the bacterial membrane

Saraogi, Ishu and Shan, Shu-ou (2014) Co-translational protein targeting to the bacterial membrane. Biochimica et Biophysica Acta - Molecular Cell Research, 1843 (8). pp. 1433-1441. ISSN 0167-4889. PMCID PMC3999308. doi:10.1016/j.bbamcr.2013.10.013.

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Co-translational protein targeting by the Signal Recognition Particle (SRP) is an essential cellular pathway that couples the synthesis of nascent proteins to their proper cellular localization. The bacterial SRP, which contains the minimal ribonucleoprotein core of this universally conserved targeting machine, has served as a paradigm for understanding the molecular basis of protein localization in all cells. In this review, we highlight recent biochemical and structural insights into the molecular mechanisms by which fundamental challenges faced by protein targeting machineries are met in the SRP pathway. Collectively, these studies elucidate how an essential SRP RNA and two regulatory GTPases in the SRP and SRP receptor (SR) enable this targeting machinery to recognize, sense and respond to its biological effectors, i.e. the cargo protein, the target membrane and the translocation machinery, thus driving efficient and faithful co-translational protein targeting. This article is part of a Special Issue entitled: Protein trafficking & Secretion.

Item Type:Article
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URLURL TypeDescription CentralArticle
Shan, Shu-ou0000-0002-6526-1733
Additional Information:© 2013 Elsevier B.V. Received 10 August 2013; Received in revised form 9 October 2013; Accepted 16 October 2013; Available online 24 October 2013. We thank Sandra Schmid, Jennifer Doudna, Peter Walter, Ramanujan Hegde, Douglas Rees, Raymond Deshaies and Bil Clemons for support and insightful discussions over the years, and David Akopian for critical reading of the manuscript. S.S. was supported by NIH grant GM078024 and by career awards from the Henry and Camille Dreyfus foundation, the Arnold and Mabel Beckman foundation, and the David and Lucile Packard foundation. I.S. was supported by a grant from the Betty and Gordon Moore Foundation.
Funding AgencyGrant Number
Camille and Henry Dreyfus FoundationUNSPECIFIED
Arnold and Mabel Beckman FoundationUNSPECIFIED
David and Lucile Packard FoundationUNSPECIFIED
Gordon and Betty Moore FoundationUNSPECIFIED
Subject Keywords:Protein targeting; SecYEG; GTPases; Molecular recognition and regulation; Ribosome
Issue or Number:8
PubMed Central ID:PMC3999308
Record Number:CaltechAUTHORS:20140106-100007866
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Official Citation:Ishu Saraogi, Shu-ou Shan, Co-translational protein targeting to the bacterial membrane, Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, Volume 1843, Issue 8, August 2014, Pages 1433-1441, ISSN 0167-4889, (
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:43221
Deposited By: Tony Diaz
Deposited On:09 Jan 2014 16:16
Last Modified:10 Nov 2021 16:34

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