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Predeliberation activity in prefrontal cortex and striatum and the prediction of subsequent value judgment

Maoz, Uri and Rutishauser, Ueli and Kim, Xinying and Cai, Xinying and Lee, Daeyeol and Koch, Christof (2013) Predeliberation activity in prefrontal cortex and striatum and the prediction of subsequent value judgment. Frontiers in Neuroscience, 7 . Art. No. 225. ISSN 1662-4548. PMCID PMC3840801.

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Rational, value-based decision-making mandates selecting the option with highest subjective expected value after appropriate deliberation. We examined activity in the dorsolateral prefrontal cortex (DLPFC) and striatum of monkeys deciding between smaller, immediate rewards and larger, delayed ones. We previously found neurons that modulated their activity in this task according to the animal's choice, while it deliberated (choice neurons). Here we found neurons whose spiking activities were predictive of the spatial location of the selected target (spatial-bias neurons) or the size of the chosen reward (reward-bias neurons) before the onset of the cue presenting the decision-alternatives, and thus before rational deliberation could begin. Their predictive power increased as the values the animals associated with the two decision alternatives became more similar. The ventral striatum (VS) preferentially contained spatial-bias neurons; the caudate nucleus (CD) preferentially contained choice neurons. In contrast, the DLPFC contained significant numbers of all three neuron types, but choice neurons were not preferentially also bias neurons of either kind there, nor were spatial-bias neurons preferentially also choice neurons, and vice versa. We suggest a simple winner-take-all (WTA) circuit model to account for the dissociation of choice and bias neurons. The model reproduced our results and made additional predictions that were borne out empirically. Our data are compatible with the hypothesis that the DLPFC and striatum harbor dissociated neural populations that represent choices and predeliberation biases that are combined after cue onset; the bias neurons have a weaker effect on the ultimate decision than the choice neurons, so their influence is progressively apparent for trials where the values associated with the decision alternatives are increasingly similar.

Item Type:Article
Related URLs:
URLURL TypeDescription CentralArticle
Maoz, Uri0000-0002-7899-1241
Rutishauser, Ueli0000-0002-9207-7069
Koch, Christof0000-0001-6482-8067
Additional Information:© 2013 Maoz, Rutishauser, Kim, Cai, Lee and Koch. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. Received: 16 August 2013; Accepted: 05 November 2013; Published online: 26 November 2013. This work was funded by the Ralph Schlaeger Charitable Foundation, FSU Big Questions in Free Will Initiative, Mathers Foundation, ONR, DARPA, and NSF, as well as the Max Planck Society and NIDA (RL1 DA024855 and P20 DA027844). We are grateful to R. Rivlin, E. Portugaly, and S. Ullman for many insightful discussions.
Group:Koch Laboratory (KLAB)
Funding AgencyGrant Number
Ralph Schlaeger Charitable FoundationUNSPECIFIED
Florida State UniversityUNSPECIFIED
Mathers FoundationUNSPECIFIED
Office of Naval Research (ONR)UNSPECIFIED
Defense Advanced Research Projects Agency (DARPA)UNSPECIFIED
Max Planck SocietyUNSPECIFIED
NIHRL1 DA024855
NIHP20 DA027844
National Institute on Drug AbuseUNSPECIFIED
Subject Keywords:pre-deliberation decision bias, value-based decision-making, decision circuit-modeling, free-choice decision making, dorsolateral prefrontal cortex, ventral striatum, caudate nucleus, monkey single-neuron recording
PubMed Central ID:PMC3840801
Record Number:CaltechAUTHORS:20140108-160215733
Persistent URL:
Official Citation:Maoz U, Rutishauser U, Kim S, Cai X, Lee D and Koch C (2013) Predeliberation activity in prefrontal cortex and striatum and the prediction of subsequent value judgment. Front. Neurosci. 7:225. doi: 10.3389/fnins.2013.00225
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:43276
Deposited By: Tony Diaz
Deposited On:15 Jan 2014 16:21
Last Modified:05 Mar 2020 00:18

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