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To be or not to be a piRNA: genomic origin and processing of piRNAs

Le Thomas, Adrien and Fejes Tóth, Katalin and Aravin, Alexei A. (2014) To be or not to be a piRNA: genomic origin and processing of piRNAs. Genome Biology, 15 (1). Art. No. 204. ISSN 1465-6906. PMCID PMC4053809.

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Piwi-interacting RNAs (piRNAs) originate from genomic regions dubbed piRNA clusters. How cluster transcripts are selected for processing into piRNAs is not understood. We discuss evidence for the involvement of chromatin structure and maternally inherited piRNAs in determining their fate.

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Additional Information:© 2014 Le Thomas et al.; licensee BioMed Central Ltd. The licensee has exclusive rights to distribute this article, in any medium, for 12 months following its publication. After this time, the article is available under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Published: 27 January 2014. We thank Evelyn Stuwe for help with figure preparation and members of the Aravin laboratory for discussion. This work was supported by grants from the National Institutes of Health (R00 HD057233, R01 GM097363 and DP2 OD007371A), the Searle Scholar, the Packard Fellowship Awards and the Ellison Medical Foundation New Scholar Aging Award.
Funding AgencyGrant Number
NIHR00 HD057233
NIHR01 GM097363
NIHDP2 OD007371A
Searle Scholars ProgramUNSPECIFIED
David and Lucile Packard FoundationUNSPECIFIED
Ellison Medical FoundationUNSPECIFIED
Issue or Number:1
PubMed Central ID:PMC4053809
Record Number:CaltechAUTHORS:20140130-080906919
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Official Citation:Le Thomas et al.: To be or not to be a piRNA: genomic origin and processing of piRNAs. Genome Biology 2014 15:204
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:43563
Deposited By: Tony Diaz
Deposited On:30 Jan 2014 22:24
Last Modified:03 Oct 2019 06:09

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