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0.5 gigapixel microscopy using a flatbed scanner

Zheng, Guoan and Ou, Xiaoze and Yang, Changhuei (2014) 0.5 gigapixel microscopy using a flatbed scanner. Biomedical Optics Express, 5 (1). pp. 1-8. ISSN 2156-7085. PMCID PMC3891323; PMC4771477.

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The capability to perform high-resolution, wide field-of-view (FOV) microscopy imaging is highly sought after in biomedical applications. In this paper, we report a wide FOV microscopy system that uses a closed-circuit-television (CCTV) lens for image relay and a flatbed scanner for data acquisition. We show that such an imaging system is capable of capturing a 10 mm × 7.5 mm FOV image with 0.78 µm resolution, resulting in more than 0.5 billion pixels across the entire image. The resolution and field curve of the proposed system were characterized by imaging a USAF resolution target and a hole-array target. To demonstrate its application, 0.5 gigapixel images of histology slides were acquired using this system.

Item Type:Article
Related URLs:
URLURL TypeDescription CentralArticle CentralErratum Paper
Zheng, Guoan0000-0002-4268-2690
Yang, Changhuei0000-0001-8791-0354
Alternate Title:Gigapixel microscopy using a flatbed scanner
Additional Information:© 2013 Optical Society of America. Received 18 Jul 2013; revised 10 Nov 2013; accepted 24 Nov 2013; published 2 Dec 2013. We acknowledge the funding support from the United States Department of Defense under grant W81XWH-09-1-0051. The scheme of this work was first presented at CLEO 2012 [22].
Errata:Xiaoze Ou, Guoan Zheng, and Changhuei Yang, "0.5 gigapixel microscopy using a flatbed scanner: erratum," Biomed. Opt. Express 7, 646-647 (2016)
Funding AgencyGrant Number
Department of DefenseW81XWH-09-1-0051
Issue or Number:1
Classification Code:OCIS codes: (120.4820) Optical systems; (170.0180) Microscopy; (170.4730) Optical pathology
PubMed Central ID:PMC3891323; PMC4771477
Record Number:CaltechAUTHORS:20140203-113756615
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Official Citation:Guoan Zheng, Xiaoze Ou, and Changhuei Yang, "0.5 gigapixel microscopy using a flatbed scanner," Biomed. Opt. Express 5, 1-8 (2014)
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:43624
Deposited On:03 Feb 2014 21:01
Last Modified:12 May 2022 18:52

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