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Frequency-Specific Alternations in the Amplitude of Low-Frequency Fluctuations in Schizophrenia

Yu, Rongjun and Chien, Yi-Ling and Wang, Hsiao-Lan Sharon and Liu, Chih-Min and Liu, Chen-Chung and Hwang, Tzung-Jeng and Hsieh, Ming H. and Hwu, Hai-Gwo and Tseng, Wen-Yih Isaac (2014) Frequency-Specific Alternations in the Amplitude of Low-Frequency Fluctuations in Schizophrenia. Human Brain Mapping, 35 (2). pp. 627-637. ISSN 1065-9471. doi:10.1002/hbm.22203. https://resolver.caltech.edu/CaltechAUTHORS:20140203-140142874

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Abstract

Schizophrenia has been associated with abnormal task-related brain activation in sensory and motor regions as well as social cognition network. Recently, two studies investigated temporal correlation between resting-state functional magnetic resonance imaging (R-fMRI) low-frequency oscillations (LFOs) in schizophrenia but reported mixed results. This may be due to the different frequency bands used in these studies. Here we utilized R-fMRI to measure the amplitude of low-frequency fluctuations (ALFF) and fractional ALFF (fALFF) in three different frequency bands (slow-5: 0.01–0.027 Hz; slow-4: 0.027–0.08 Hz; and typical band: 0.01–0.08 Hz) in 69 patients with schizophrenia and 62 healthy controls. We showed that there were significant differences in ALFF/fALFF between the two bands (slow-5 and slow-4) in regions including basal ganglia, midbrain, and ventromedial prefrontal cortex. Importantly, we also identified significant interaction between frequency bands and groups in inferior occipital gyrus, precunus, and thalamus. The results suggest that the abnormalities of LFOs in schizophrenia is dependent on the frequency band and suggest that future studies should take the different frequency bands into account when measure intrinsic brain activity.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1002/hbm.22203DOIArticle
ORCID:
AuthorORCID
Yu, Rongjun0000-0003-0123-1524
Additional Information:© 2012 Wiley Periodicals, Inc. Received for publication 13 February 2012; Revised 30 July 2012; Accepted 21 August 2012. Published online 5 November 2012 in Wiley Online Library. Rongjun Yu and Yi-Ling Chien contributed equally to this work. Contract grant sponsor: National Science Council, Taiwan; Contract grant numbers: NSC100-3112-B-002-016, NSC100-2321-B-002-015; Contract grant sponsor: National Health Research Institute, Taiwan; Contract grant number: NHRI-EX101-10145NI; Contract grant sponsor: Department of Medical Imaging and Advanced Biomedical MRI Laboratory; National Taiwan University Hospital, Taipei, Taiwan. The authors thank all of the participants for their involvement in this study.
Funders:
Funding AgencyGrant Number
National Science Council (Taipei)NSC100-3112-B-002-016
National Science Council (Taipei)NSC100-2321-B- 002-015
National Science Council (Taipei)NHRI-EX101-10145NI
National Taiwan University Hospital,UNSPECIFIED
Subject Keywords:schizophrenia; low-frequency fluctuation; prefrontal cortex; basal ganglia; resting state; MRI
Issue or Number:2
DOI:10.1002/hbm.22203
Record Number:CaltechAUTHORS:20140203-140142874
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20140203-140142874
Official Citation:Yu, R., Chien, Y.-L., Wang, H.-L. S., Liu, C.-M., Liu, C.-C., Hwang, T.-J., Hsieh, M. H., Hwu, H.-G. and Tseng, W.-Y. I. (2014), Frequency-specific alternations in the amplitude of low-frequency fluctuations in schizophrenia. Hum. Brain Mapp., 35: 627–637. doi: 10.1002/hbm.22203
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:43627
Collection:CaltechAUTHORS
Deposited By: Ruth Sustaita
Deposited On:03 Feb 2014 22:43
Last Modified:10 Nov 2021 16:40

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