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Expression and function of transcription factor cMyb during cranial neural crest development

Betancur, Paola and Simões-Costa, Marcos and Sauka-Spengler, Tatjana and Bronner, Marianne E. (2014) Expression and function of transcription factor cMyb during cranial neural crest development. Mechanisms of Development, 132 . pp. 38-43. ISSN 0925-4773. PMCID PMC3987950. doi:10.1016/j.mod.2014.01.005.

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The transcription factor cMyb has well known functions in vertebrate hematopoiesis, but little was known about its distribution or function at early developmental stages. Here, we show that cMyb transcripts are present at the neural plate during gastrulation in chick embryos. cMyb expression then resolves to the cranial neural folds and is maintained in early migrating cranial neural crest cells during and after neurulation. Morpholino-mediated knock-down of cMyb reduces expression of Pax7 and Twist at the neural plate border, as well as reducing expression of neural crest specifier genes Snail2 and Sox10 and completely eliminating expression of Ets1. On the other hand, its loss results in abnormal maintenance of Zic1, but little or no effect on other neural crest specifier genes like FoxD3 or Sox9. These results place cMyb in a critical hierarchical position within the cranial neural crest cell gene regulatory network, likely directly inhibiting Zic1 and upstream of Ets1 and some, but not all, neural crest specifier genes.

Item Type:Article
Related URLs:
URLURL TypeDescription CentralArticle
Simões-Costa, Marcos0000-0003-1452-7068
Sauka-Spengler, Tatjana0000-0001-9289-0263
Bronner, Marianne E.0000-0003-4274-1862
Additional Information:© 2014 Published by Elsevier Ireland Ltd. Received 30 October 2013. Received in revised form 26 January 2014. Accepted 29 January 2014. Available online 6 February 2014. This work is supported by USPHS P01 HD037105.
Funding AgencyGrant Number
NIHP01 HD037105
Subject Keywords:Neural crest; Neural plate border; Gene regulatory network; cMyb; Transcription factor
PubMed Central ID:PMC3987950
Record Number:CaltechAUTHORS:20140213-104955432
Persistent URL:
Official Citation:Paola Betancur, Marcos Simões-Costa, Tatjana Sauka-Spengler, Marianne E. Bronner, Expression and function of transcription factor cMyb during cranial neural crest development, Mechanisms of Development, Volume 132, May 2014, Pages 38-43, ISSN 0925-4773, (
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:43811
Deposited By: Tony Diaz
Deposited On:13 Feb 2014 21:52
Last Modified:10 Nov 2021 16:43

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