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Design and synthesis of oligoamide-based double α-helix mimetics

Kulikov, Oleg V. and Thompson, Sam and Xu, Hai and Incarvito, Christopher D. and Scott, Richard T. and Saraogi, Ishu and Nevola, Laura and Hamilton, Andrew D. (2013) Design and synthesis of oligoamide-based double α-helix mimetics. In: 246th ACS National Meeting & Exposition, Sept. 8-12, 2013, Indianapolis, IN. https://resolver.caltech.edu/CaltechAUTHORS:20140213-150022614

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Abstract

An extensive series of bis-oligobenzamides and bisoligopyridylamides were efficiently prepd. and studied by X-ray anal. and computation. A modular synthesis gave double α-helix mimics bearing between two and ten branched side-chains. The inter-helix angle and distance can be tuned by varying the length and rigidity of spacer, thus reproducing the recognition domains of a range of super-secondary structures.


Item Type:Conference or Workshop Item (Paper)
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http://www.acs.org/content/acs/en/meetings/fall-2013.htmlOrganizationConference Website
Additional Information:© 2013 American Chemical Society.
Record Number:CaltechAUTHORS:20140213-150022614
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20140213-150022614
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:43822
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:25 Mar 2014 17:38
Last Modified:03 Oct 2019 06:11

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