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Sensational placodes: Neurogenesis in the otic and olfactory systems

Maier, Esther C. and Saxena, Ankur and Alsina, Berta and Bronner, Marianne E. and Whitfield, Tanya T. (2014) Sensational placodes: Neurogenesis in the otic and olfactory systems. Developmental Biology, 389 (1). pp. 50-67. ISSN 0012-1606. PMCID PMC3988839. https://resolver.caltech.edu/CaltechAUTHORS:20140214-111259034

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Abstract

For both the intricate morphogenetic lay out of the sensory cells in the ear and the elegantly radial arrangement of the sensory neurons in the nose, numerous signaling molecules and genetic determinants are required in concert to generate these specialized neuronal populations that help connect us to our environment. In this review, we outline many of the proteins and pathways that play essential roles in the differentiation of otic and olfactory neurons and their integration into their non-neuronal support structures. In both cases, well-known signaling pathways together with region-specific factors transform thickened ectodermal placodes into complex sense organs containing numerous, diverse neuronal subtypes. Olfactory and otic placodes, in combination with migratory neural crest stem cells, generate highly specialized subtypes of neuronal cells that sense sound, position and movement in space, odors and pheromones throughout our lives.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1016/j.ydbio.2014.01.023DOIArticle
http://www.sciencedirect.com/science/article/pii/S0012160614000517PublisherArticle
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3988839/PubMed CentralArticle
ORCID:
AuthorORCID
Saxena, Ankur0000-0001-8646-2887
Bronner, Marianne E.0000-0003-4274-1862
Additional Information:© 2014 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY license. Open Access funded by Biotechnology and Biological Sciences Research Council. Available online 6 February 2014. We thank Leila Abbas and Lena Gunhaga for providing images or for permission to use images; Robert Kelsh for the Tg(–4.9sox10:eGFP) line and Yoshihiro Yoshihara, RIKEN BSI, and the National Bioresource Project of Japan for the Tg(TRPC24.5k:gap-Venus)/rw037 and Tg(OMP2k:lyn-mRFP)/rw035 lines that are featured in the figures. ECM was funded by a Marie Curie Intra European Fellowship (275978). This work was supported by the following grants: BFU2001-27006 to BA, NIH grants DE16459 and DC011577 to MEB, and a BBSRC project grant BB/J003050 to TTW.
Funders:
Funding AgencyGrant Number
Marie Curie Fellowship275978
Universitat Pompeu FabraBFU2001-27006
NIHDE16459
NIHDC011577
Biotechnology and Biological Sciences Research Council (BBSRC)BB/J003050
Subject Keywords:Otic; Olfactory; Neurogenesis; Hair cell; Sensory neuron
Issue or Number:1
PubMed Central ID:PMC3988839
Record Number:CaltechAUTHORS:20140214-111259034
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20140214-111259034
Official Citation:Esther C. Maier, Ankur Saxena, Berta Alsina, Marianne E. Bronner, Tanya T. Whitfield, Sensational placodes: Neurogenesis in the otic and olfactory systems, Developmental Biology, Volume 389, Issue 1, 1 May 2014, Pages 50-67, ISSN 0012-1606, http://dx.doi.org/10.1016/j.ydbio.2014.01.023. (http://www.sciencedirect.com/science/article/pii/S0012160614000517)
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:43838
Collection:CaltechAUTHORS
Deposited By: Michelle Trinh
Deposited On:18 Feb 2014 18:58
Last Modified:03 Oct 2019 06:11

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