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Structural Insights on the Role of Antibodies in HIV-1 Vaccine and Therapy

West, Anthony P., Jr. and Scharf, Louise and Scheid, Johannes F. and Klein, Florian and Bjorkman, Pamela J. and Nussenzweig, Michel C. (2014) Structural Insights on the Role of Antibodies in HIV-1 Vaccine and Therapy. Cell, 156 (4). pp. 633-648. ISSN 0092-8674. PMCID PMC4041625. https://resolver.caltech.edu/CaltechAUTHORS:20140220-100322233

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Abstract

Despite 30 years of effort, there is no effective vaccine for HIV-1. However, antibodies can prevent HIV-1 infection in humanized mice and macaques when passively transferred. New single-cell-based methods have uncovered many broad and potent donor-derived antibodies, and structural studies have revealed the molecular bases for their activities. The new data suggest why such antibodies are difficult to elicit and inform HIV-1 vaccine development efforts. In addition to protecting against infection, the newly identified antibodies can suppress active infections in mice and macaques, suggesting they could be valuable additions to anti-HIV-1 therapies and to strategies to eradicate HIV-1 infection.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1016/j.cell.2014.01.052DOIArticle
http://www.sciencedirect.com/science/article/pii/S0092867414001469PublisherArticle
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4041625/PubMed CentralArticle
ORCID:
AuthorORCID
Bjorkman, Pamela J.0000-0002-2277-3990
Nussenzweig, Michel C.0000-0003-0592-8564
Additional Information:© 2014 Elsevier Inc. Available online 13 February 2014. We thank Susan Zolla-Pazner for helpful discussions and critical review. This work was supported by a Collaboration for AIDS Vaccine Discovery (CAVD) grant from the Bill and Melinda Gates Foundation (Grant ID: 1040753 to P.J.B. and M.C.N.), National Institutes of Health grant HIVRAD P01 AI100148 (P.J.B. and M.C.N.) and award number DP1OD006961 (to P.J.B.), NIH Center for HIV/AID Vaccine Immunology and Immunogen Discovery (CHAVI-ID) 1UM1 AI100663-01 (M.C.N.), and the American Cancer Society (Grant PF-13-076-01-MPC to L.S.). F.K. was supported by the Stavros Niarchos Foundation.
Funders:
Funding AgencyGrant Number
Collaboration for AIDS Vaccine DiscoveryUNSPECIFIED
Bill and Melinda Gates Foundation1040753
NIHHIVRAD P01 AI100148
NIHDP1OD006961
NIH1UM1 AI100663-01
American Cancer SocietyPF-13-076-01-MPC
Stavros Niarchos FoundationUNSPECIFIED
Issue or Number:4
PubMed Central ID:PMC4041625
Record Number:CaltechAUTHORS:20140220-100322233
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20140220-100322233
Official Citation:West Jr, Anthony P., Scharf, L., Scheid, Johannes F., Klein, F., Bjorkman, Pamela J., & Nussenzweig, Michel C. (2014). Structural Insights on the Role of Antibodies in HIV-1 Vaccine and Therapy. Cell, 156(4), 633-648. doi: http://dx.doi.org/10.1016/j.cell.2014.01.052
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:43888
Collection:CaltechAUTHORS
Deposited By: Jason Perez
Deposited On:20 Feb 2014 22:39
Last Modified:03 Oct 2019 06:12

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