Sideris, Constantine and Hajimiri, Ali (2013) Design and Implementation of an Integrated Magnetic Spectrometer for Multiplexed Biosensing. IEEE Transactions on Biomedical Circuits and Systems, 7 (6). pp. 773-784. ISSN 1932-4545. doi:10.1109/TBCAS.2013.2297514. https://resolver.caltech.edu/CaltechAUTHORS:20140221-094415202
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Abstract
Magnetic spectroscopy allows for characterization of the magnetic susceptibility of magnetic beads across a broad frequency range. This enables differentiation and quantification of multiple beads of varying types concurrently present in the active volume of a sensor's surface. A magnetic spectrometer can be used for multi-probe tagging and identification akin to multi-color fluorescent bio-sensing. We propose a new sensing methodology to perform magnetic spectroscopy and analyze various important design parameters such as SNR and gain uniformity. We present a proof-of-concept design of a fully integrated CMOS magnetic spectrometer that can detect, quantify, and characterize magnetic materials in the 1.1 GHz to 3.3 GHz frequency range, where we demonstrate magnetic multiplexing capability using a mixture of two different kinds of magnetic beads. The sensor consumes less than 2 mW of DC power within the whole frequency range, requires no external biasing magnetic fields, is implemented in a standard CMOS process, and can be powered and operated completely from a USB interface. The magnetic spectrometer not only increases the throughput and multiplexing of biosensing experiments for a given sensor area, but also can enable additional applications, such as magnetic flow cytometry and signal-collocation assays of multiple probes.
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| Additional Information: | © 2014 IEEE. Manuscript received October 19, 2013; revised November 30, 2013; accepted December 08, 2013. Date of publication January 17, 2014; date of current version January 28, 2014. This work was supported in part by a National Science Foundation fellowship: DGE-1144469. This paper was recommended by Associate Editor S. Gambini. The authors would like to thank Prof. H. Wang and the members of the Caltech High-speed Integrated Circuits (CHIC) group for their helpful discussions. They would also like to thank Y. E. Wang for help with sample preparation, Dr. D. Belot of ST Microelectronics for technical support, ST Microelectronics for chip fabrication, and the anonymous reviewers for their constructive feedback. | |||||||||
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| Subject Keywords: | Chemical and biological sensors; CMOS integrated circuits; magnetic sensors; medical diagnosis; multi-probe; multiplexed detection | |||||||||
| Issue or Number: | 6 | |||||||||
| DOI: | 10.1109/TBCAS.2013.2297514 | |||||||||
| Record Number: | CaltechAUTHORS:20140221-094415202 | |||||||||
| Persistent URL: | https://resolver.caltech.edu/CaltechAUTHORS:20140221-094415202 | |||||||||
| Official Citation: | Sideris, C.; Hajimiri, A., "Design and Implementation of an Integrated Magnetic Spectrometer for Multiplexed Biosensing," Biomedical Circuits and Systems, IEEE Transactions on , vol.7, no.6, pp.773,784, Dec. 2013 doi: 10.1109/TBCAS.2013.2297514 URL: http://ieeexplore.ieee.org/stamp/stamp.jsp?tp=&arnumber=6716067&isnumber=6722950 | |||||||||
| Usage Policy: | No commercial reproduction, distribution, display or performance rights in this work are provided. | |||||||||
| ID Code: | 43922 | |||||||||
| Collection: | CaltechAUTHORS | |||||||||
| Deposited By: | Tony Diaz | |||||||||
| Deposited On: | 28 Feb 2014 16:21 | |||||||||
| Last Modified: | 10 Nov 2021 16:45 |
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