A Caltech Library Service

A Bio-Inspired Approach for the Reduction of Left Ventricular Workload

Pahlevan, Niema M. and Gharib, Morteza (2014) A Bio-Inspired Approach for the Reduction of Left Ventricular Workload. PLoS ONE, 9 (1). Art. No. e87122. ISSN 1932-6203. PMCID PMC3901771.

PDF - Published Version
Creative Commons Attribution.

[img] MS Word (Appendix S1) - Supplemental Material
Creative Commons Attribution.

[img] Archive (ZIP) (Data S1) - Supplemental Material
Creative Commons Attribution.


Use this Persistent URL to link to this item:


Previous studies have demonstrated the existence of optimization criteria in the design and development of mammalians cardiovascular systems. Similarities in mammalian arterial wave reflection suggest there are certain design criteria for the optimization of arterial wave dynamics. Inspired by these natural optimization criteria, we investigated the feasibility of optimizing the aortic waves by modifying wave reflection sites. A hydraulic model that has physical and dynamical properties similar to a human aorta and left ventricle was used for a series of in-vitro experiments. The results indicate that placing an artificial reflection site (a ring) at a specific location along the aorta may create a constructive wave dynamic that could reduce LV pulsatile workload. This simple bio-inspired approach may have important implications for the future of treatment strategies for diseased aorta.

Item Type:Article
Related URLs:
URLURL TypeDescription
Gharib, Morteza0000-0002-2204-9302
Additional Information:© 2014 Pahlevan, Gharib. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Received: October 27, 2013; Accepted: December 19, 2013; Published: January 24, 2014. Author Contributions: Conceived and designed the experiments: NMP MG. Performed the experiments: NMP. Analyzed the data: NMP MG. Wrote the paper: NMP MG. Niema M. Pahlevan acknowledges support from the American Heart Association (AHA) Predoctoral fellowship (Award Id: 12PRE9610015). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
Funding AgencyGrant Number
American Heart Association12PRE9610015
Issue or Number:1
PubMed Central ID:PMC3901771
Record Number:CaltechAUTHORS:20140228-100354713
Persistent URL:
Official Citation:Pahlevan NM, Gharib M (2014) A Bio-Inspired Approach for the Reduction of Left Ventricular Workload. PLoS ONE 9(1): e87122. doi:10.1371/journal.pone.0087122
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:44053
Deposited By: Jason Perez
Deposited On:28 Feb 2014 21:53
Last Modified:10 Feb 2020 22:47

Repository Staff Only: item control page