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Genetic Control of Wiring Specificity in the Fly Olfactory System

Hong, Weizhe and Luo, Liqun (2014) Genetic Control of Wiring Specificity in the Fly Olfactory System. Genetics, 196 (1). pp. 17-29. ISSN 0016-6731. PMCID PMC3872183. http://resolver.caltech.edu/CaltechAUTHORS:20140306-093522068

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Abstract

Precise connections established between pre- and postsynaptic partners during development are essential for the proper function of the nervous system. The olfactory system detects a wide variety of odorants and processes the information in a precisely connected neural circuit. A common feature of the olfactory systems from insects to mammals is that the olfactory receptor neurons (ORNs) expressing the same odorant receptor make one-to-one connections with a single class of second-order olfactory projection neurons (PNs). This represents one of the most striking examples of targeting specificity in developmental neurobiology. Recent studies have uncovered central roles of transmembrane and secreted proteins in organizing this one-to-one connection specificity in the olfactory system. Here, we review recent advances in the understanding of how this wiring specificity is genetically controlled and focus on the mechanisms by which transmembrane and secreted proteins regulate different stages of the Drosophila olfactory circuit assembly in a coordinated manner. We also discuss how combinatorial coding, redundancy, and error-correcting ability could contribute to constructing a complex neural circuit in general.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1534/genetics.113.154336DOIArticle
http://www.genetics.org/content/196/1/17PublisherArticle
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3872183/PubMed CentralArticle
Additional Information:© 2014 by the Genetics Society of America. Manuscript received September 20, 2013; accepted for publication November 7, 2013. The authors thank A. Ward, W. Joo, X. Gao, J. Charalel, F. Ding, B. Wu, E. Wu, and Y. Hong for commenting on the manuscript. W. Hong is a Helen Hay Whitney Fellow. L. Luo is an investigator of the Howard Hughes Medical Institute. Research on the olfactory circuit wiring in the Luo laboratory has been supported by National Institutes of Health grant R01 DC-005982.
Funders:
Funding AgencyGrant Number
Howard Hughes Medical Institute (HHMI)UNSPECIFIED
NIHR01 DC-005982
Subject Keywords:Drosophila; olfactory system; wiring specificity; transmembrane and secreted proteins; cell–cell interaction
PubMed Central ID:PMC3872183
Record Number:CaltechAUTHORS:20140306-093522068
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:20140306-093522068
Official Citation:Hong, W., & Luo, L. (2014). Genetic Control of Wiring Specificity in the Fly Olfactory System. Genetics, 196(1), 17-29. doi: 10.1534/genetics.113.154336
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:44170
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:06 Mar 2014 23:06
Last Modified:21 Jul 2017 19:45

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