Hong, Weizhe and Luo, Liqun (2014) Genetic Control of Wiring Specificity in the Fly Olfactory System. Genetics, 196 (1). pp. 17-29. ISSN 0016-6731. PMCID PMC3872183. https://resolver.caltech.edu/CaltechAUTHORS:20140306-093522068
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Abstract
Precise connections established between pre- and postsynaptic partners during development are essential for the proper function of the nervous system. The olfactory system detects a wide variety of odorants and processes the information in a precisely connected neural circuit. A common feature of the olfactory systems from insects to mammals is that the olfactory receptor neurons (ORNs) expressing the same odorant receptor make one-to-one connections with a single class of second-order olfactory projection neurons (PNs). This represents one of the most striking examples of targeting specificity in developmental neurobiology. Recent studies have uncovered central roles of transmembrane and secreted proteins in organizing this one-to-one connection specificity in the olfactory system. Here, we review recent advances in the understanding of how this wiring specificity is genetically controlled and focus on the mechanisms by which transmembrane and secreted proteins regulate different stages of the Drosophila olfactory circuit assembly in a coordinated manner. We also discuss how combinatorial coding, redundancy, and error-correcting ability could contribute to constructing a complex neural circuit in general.
Item Type: | Article | ||||||||||||
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Additional Information: | © 2014 by the Genetics Society of America. Manuscript received September 20, 2013; accepted for publication November 7, 2013. The authors thank A. Ward, W. Joo, X. Gao, J. Charalel, F. Ding, B. Wu, E. Wu, and Y. Hong for commenting on the manuscript. W. Hong is a Helen Hay Whitney Fellow. L. Luo is an investigator of the Howard Hughes Medical Institute. Research on the olfactory circuit wiring in the Luo laboratory has been supported by National Institutes of Health grant R01 DC-005982. | ||||||||||||
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Subject Keywords: | Drosophila; olfactory system; wiring specificity; transmembrane and secreted proteins; cell–cell interaction | ||||||||||||
Issue or Number: | 1 | ||||||||||||
PubMed Central ID: | PMC3872183 | ||||||||||||
Record Number: | CaltechAUTHORS:20140306-093522068 | ||||||||||||
Persistent URL: | https://resolver.caltech.edu/CaltechAUTHORS:20140306-093522068 | ||||||||||||
Official Citation: | Hong, W., & Luo, L. (2014). Genetic Control of Wiring Specificity in the Fly Olfactory System. Genetics, 196(1), 17-29. doi: 10.1534/genetics.113.154336 | ||||||||||||
Usage Policy: | No commercial reproduction, distribution, display or performance rights in this work are provided. | ||||||||||||
ID Code: | 44170 | ||||||||||||
Collection: | CaltechAUTHORS | ||||||||||||
Deposited By: | Tony Diaz | ||||||||||||
Deposited On: | 06 Mar 2014 23:06 | ||||||||||||
Last Modified: | 03 Oct 2019 06:15 |
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