CaltechAUTHORS
  A Caltech Library Service

Clinical Uncertainties, Health Service Challenges, and Ethical Complexities of HIV “Test-and-Treat”: A Systematic Review

Kulkarni, Sonali P. and Shah, Kavita R. and Sarma, Karthik V. and Mahajan, Anish P. (2013) Clinical Uncertainties, Health Service Challenges, and Ethical Complexities of HIV “Test-and-Treat”: A Systematic Review. American Journal of Public Health, 103 (6). E14-E23. ISSN 0090-0036. https://resolver.caltech.edu/CaltechAUTHORS:20140319-094721621

Full text is not posted in this repository. Consult Related URLs below.

Use this Persistent URL to link to this item: https://resolver.caltech.edu/CaltechAUTHORS:20140319-094721621

Abstract

Despite the HIV “test-and-treat” strategy’s promise, questions about its clinical rationale, operational feasibility, and ethical appropriateness have led to vigorous debate in the global HIV community. We performed a systematic review of the literature published between January 2009 and May 2012 using PubMed, SCOPUS, Global Health, Web of Science, BIOSIS, Cochrane CENTRAL, EBSCO Africa-Wide Information, and EBSCO CINAHL Plus databases to summarize clinical uncertainties, health service challenges, and ethical complexities that may affect the test-and-treat strategy’s success. A thoughtful approach to research and implementation to address clinical and health service questions and meaningful community engagement regarding ethical complexities may bring us closer to safe, feasible, and effective test-and-treat implementation.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.2105/AJPH.2013.301273DOIArticle
http://ajph.aphapublications.org/doi/abs/10.2105/AJPH.2013.301273PublisherArticle
Additional Information:© 2013 American Public Health Association. Accepted on: Feb 1, 2013. This research was supported by the University of California, Los Angeles (UCLA), Robert Wood Johnson Foundation Clinical Scholars Program (to S. P. K.); the National Institutes of Health (NIH), National Institute of General Medical Sciences (grant GM08042 to K. V. S.); the UCLA-Caltech Medical Scientist Training Program (to K. V. S.); the Centers for AIDS Research (grant 5P30 AI028697 to A. P. M.); the UCLA AIDS Institute (to A. P. M.); and the UCLA Clinical and Translational Science Institute (grant 1UL 1RR033 176 to A. P. M.). The authors thank Shilpa Sayana, MD, MPH, for helpful discussion and comments on earlier versions of this article. Contributors: S. P. Kulkarni and A. P. Mahajan were responsible for the conceptualization and design of the study. S. P. Kulkarni led the writing of the article. All authors participated in developing the review protocol, reviewing articles for inclusion criteria, extracting data from the articles, interpreting the data, and revising the article; all approved the final version. Human Participant Protection: No protocol approval was necessary because data were obtained from secondary sources.
Funders:
Funding AgencyGrant Number
University of California Los Angeles (UCLA)UNSPECIFIED
Robert Wood Johnson Foundation Clinical Scholars ProgramUNSPECIFIED
NIHUNSPECIFIED
National Institute of General Medical SciencesGM08042
UCLA-Caltech Medical Scientist Training ProgramUNSPECIFIED
Centers for AIDS Research5P30 AI028697
UCLA AIDS InstituteUNSPECIFIED
UCLA Clinical and Translational Science Institute1UL 1RR033 176
Issue or Number:6
Record Number:CaltechAUTHORS:20140319-094721621
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20140319-094721621
Official Citation: Clinical Uncertainties, Health Service Challenges, and Ethical Complexities of HIV “Test-and-Treat”: A Systematic Review Sonali P. Kulkarni, Kavita R. Shah, Karthik V. Sarma, and Anish P. Mahajan American Journal of Public Health 2013 103:6, e14-e23
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:44389
Collection:CaltechAUTHORS
Deposited By: Ruth Sustaita
Deposited On:19 Mar 2014 17:20
Last Modified:03 Oct 2019 06:17

Repository Staff Only: item control page