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Development of functional assays for p97/VCP inhibition

Shi, Yihui and Liu, Xiaohe and Calaoagan, Joy and Samuelson, Steven and Chou, Tsui-Fen and Deshaies, Raymond J. and Sambucetti, Lidia C. (2013) Development of functional assays for p97/VCP inhibition. Cancer Research, 73 (8). Art. No. 2146. ISSN 0008-5472. doi:10.1158/1538-7445.AM2013-2146.

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p97 (also called VCP in metazoans and CDC48 in yeast) is a highly conserved, ubiquitously expressed, and essential AAA ATPase. p97 plays a key role in endoplasmic reticulum-associated degradation of misfolded secretory and membrane proteins as well as ubiquitin-dependent turnover of a subset of cytoplasmic substrates of the ubiquitin-proteasome system.

Item Type:Article
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URLURL TypeDescription
Chou, Tsui-Fen0000-0003-2410-2186
Deshaies, Raymond J.0000-0002-3671-9354
Additional Information:© 2013 American Association for Cancer Research. Funded by NExT Chemical Biology Consortium, NCI Contract No. HHSN261200800001E.
Funding AgencyGrant Number
NExT Chemical Biology ConsortiumUNSPECIFIED
National Cancer InstituteHHSN261200800001E
Issue or Number:8
Record Number:CaltechAUTHORS:20140325-082556135
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Official Citation:Yihui Shi, Xiaohe Liu, Joy Calaoagan, Steven Samuelsson, Tsui-Fen Chou, Raymond J. Deshaies, Lidia C. Sambucetti. Development of functional assays for p97/VCP inhibition. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 2146. doi:10.1158/1538-7445.AM2013-2146
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:44489
Deposited By: Ruth Sustaita
Deposited On:25 Mar 2014 18:11
Last Modified:10 Nov 2021 16:52

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