CaltechAUTHORS
  A Caltech Library Service

Use of iterative in situ click chemistry to develop a capture agent specific for a transforming point mutation in the pleckstrin homology domain of Akt1

Deyle, Kaycie M. and Hee, Ying Qiao and Millward, Steven and Heath, James (2013) Use of iterative in situ click chemistry to develop a capture agent specific for a transforming point mutation in the pleckstrin homology domain of Akt1. Cancer Research, 73 (8). Art. No. LB-4. ISSN 0008-5472. https://resolver.caltech.edu/CaltechAUTHORS:20140326-081558923

Full text is not posted in this repository. Consult Related URLs below.

Use this Persistent URL to link to this item: https://resolver.caltech.edu/CaltechAUTHORS:20140326-081558923

Abstract

We present an iterative in situ click chemistry approach to sequentially assemble peptide ligands that can selectively bind to and inhibit a transforming point mutation (E17K) found in the Pleckstrin Homology Domain (PHD) of the Akt1 kinase. The Akt1 kinase plays a critical role in the PI3K signaling pathway - the activation of which is closely linked to tumor development and cancer cell survival. It has recently been shown that the E17K mutation in the PHD of Akt1 results in an increased affinity of the PHD for the PIP3 substrate. Consequently, deregulated recruitment of Akt1 to the cell membrane causes constitutive activation of the PI3K pathway, which has been shown to induce leukemia in mice.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1158/1538-7445.AM2013-LB-4DOIArticle
http://cancerres.aacrjournals.org/cgi/content/short/73/8_MeetingAbstracts/LB-4PublisherArticle
ORCID:
AuthorORCID
Heath, James0000-0001-5356-4385
Additional Information:© 2013 American Association for Cancer Research. Proceedings: AACR 104th Annual Meeting 2013; Apr 6-10, 2013; Washington, DC.
Issue or Number:8
Record Number:CaltechAUTHORS:20140326-081558923
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20140326-081558923
Official Citation:Kaycie M. Deyle, Ying Qiao Hee, Steven Millward, James Heath. Use of iterative in situ click chemistry to develop a capture agent specific for a transforming point mutation in the pleckstrin homology domain of Akt1. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr LB-4. doi:10.1158/1538-7445.AM2013-LB-4
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:44516
Collection:CaltechAUTHORS
Deposited By: Ruth Sustaita
Deposited On:26 Mar 2014 19:50
Last Modified:03 Oct 2019 06:18

Repository Staff Only: item control page