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A wave dynamics criterion for optimization of mammalian cardiovascular system

Pahlevan, Niema M. and Gharib, Morteza (2014) A wave dynamics criterion for optimization of mammalian cardiovascular system. Journal of Biomechanics, 47 (7). pp. 1727-1732. ISSN 0021-9290 . https://resolver.caltech.edu/CaltechAUTHORS:20140401-142653091

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Abstract

The cardiovascular system in mammals follows various optimization criteria covering the heart, the vascular network, and the coupling of the two. Through a simple dimensional analysis we arrived at a non-dimensional number (wave condition number) that can predict the optimum wave state in which the left ventricular (LV) pulsatile power (LV workload) is minimized in a mammalian cardiovascular system. This number is also universal among all mammals independent of animal size maintaining a value of around 0.1. By utilizing a unique in vitro model of human aorta, we tested our hypothesis against a wide range of aortic compliance (pulse wave velocity). We concluded that the optimum value of the wave condition number remains to be around 0.1 for a wide range of aorta compliance that we could simulate in our in-vitro system.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1016/j.jbiomech.2014.02.014DOIArticle
http://www.sciencedirect.com/science/article/pii/S0021929014001080PublisherArticle
Additional Information:© 2014 Elsevier Ltd. Accepted 13 February 2014. Niema M. Pahlevan acknowledges support from the American Heart Association (AHA) Predoctoral fellowship (Award Id: 12PRE9610015)
Group:GALCIT
Funders:
Funding AgencyGrant Number
American Heart Association (AHA) Predoctoral Fellowship12PRE9610015
Subject Keywords:Mammalian cardiovascular system; Optimum heart rate; Aorta; Hemodynamics; Arterial wave reflection; Left ventricular workload
Issue or Number:7
Record Number:CaltechAUTHORS:20140401-142653091
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20140401-142653091
Official Citation:Niema M. Pahlevan, Morteza Gharib, A wave dynamics criterion for optimization of mammalian cardiovascular system, Journal of Biomechanics, Volume 47, Issue 7, 7 May 2014, Pages 1727-1732, ISSN 0021-9290, http://dx.doi.org/10.1016/j.jbiomech.2014.02.014. (http://www.sciencedirect.com/science/article/pii/S0021929014001080)
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:44586
Collection:CaltechAUTHORS
Deposited By: Ruth Sustaita
Deposited On:01 Apr 2014 22:41
Last Modified:03 Oct 2019 06:19

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