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Bacterial mechanosensitive channels: progress towards an understanding of their roles in cell physiology

Booth, Ian R. (2014) Bacterial mechanosensitive channels: progress towards an understanding of their roles in cell physiology. Current Opinion in Microbiology, 18 . pp. 16-22. ISSN 1369-5274. PMCID PMC4005912. http://resolver.caltech.edu/CaltechAUTHORS:20140403-100546813

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Abstract

Bacterial mechanosensitive channels sense the changes in lateral tension in the bilayer of the cytoplasmic membrane generated by rapid water flow into the cell. Two major structural families are found widely distributed across bacteria and archaea: MscL and MscS. Our understanding of the mechanisms of gating has advanced rapidly through genetic analysis, structural biology and electrophysiology. It is only recently that the analysis of the physiological roles of the channels has kept pace with mechanistic studies. Recent advances have increased our understanding of the role of the channels in preventing structural perturbation during osmotic transitions and its relationship to water flow across the membrane. It is to these recent developments that this review is dedicated.


Item Type:Article
Related URLs:
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http://dx.doi.org/10.1016/j.mib.2014.01.005DOIArticle
http://www.sciencedirect.com/science/article/pii/S1369527414000071PublisherArticle
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4005912/PubMed CentralArticle
Additional Information:© 2014 The Author. Published by Elsevier Ltd. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-No Derivative Works License, which permits non-commercial use, distribution, and reproduction in any medium, provided the original author and source are credited. Thanks to all members of the Aberdeen group, collaborators and friends whose discussions have spurred the development of the MS channel field. Special thanks to Doug Rees, Diane Newman and Rob Phillips for their support and hospitality at Caltech. Unique insights have been provided by members of the Newman and Phillips research groups, particularly, Caj Neubauer, Gargi Kulkarni and Megan Bergkessel, Heun Jin Lee and Maja Bialecka-Fornal. The author’s research on MS channels is supported by a grant from The Wellcome Trust (WT092552MA) and the BBSRC (BB/ H017917/1). The author is a Leverhulme Emeritus Fellow and this work was supported in part by a CEMI Visiting Faculty Fellowship from Caltech.
Group:Caltech Center for Environmental Microbial Interactions (CEMI)
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Funding AgencyGrant Number
Wellcome TrustWT092552MA
Biotechnology and Biological Sciences Research Council (BBSRC)BB/H017917/1
Caltech Center for Environmental Microbial Interactions (CEMI)UNSPECIFIED
PubMed Central ID:PMC4005912
Record Number:CaltechAUTHORS:20140403-100546813
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:20140403-100546813
Official Citation:Ian R Booth, Bacterial mechanosensitive channels: progress towards an understanding of their roles in cell physiology, Current Opinion in Microbiology, Volume 18, April 2014, Pages 16-22, ISSN 1369-5274, http://dx.doi.org/10.1016/j.mib.2014.01.005. (http://www.sciencedirect.com/science/article/pii/S1369527414000071)
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:44629
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:03 Apr 2014 19:08
Last Modified:20 Oct 2017 20:58

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