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Activity in dlPFC and its effective connectivity to vmPFC are associated with temporal discounting

Hare, Todd A. and Hakimi, Shabnam and Rangel, Antonio (2014) Activity in dlPFC and its effective connectivity to vmPFC are associated with temporal discounting. Frontiers in Neuroscience, 8 . Art. No. 50. ISSN 1662-4548. doi:10.3389/fnins.2014.00050.

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There is widespread interest in identifying computational and neurobiological mechanisms that influence the ability to choose long-term benefits over more proximal and readily available rewards in domains such as dietary and economic choice. We present the results of a human fMRI study that examines how neural activity relates to observed individual differences in the discounting of future rewards during an intertemporal monetary choice task. We found that a region of left dorsolateral prefrontal cortex (dlPFC) BA-46 was more active in trials where subjects chose delayed rewards, after controlling for the subjective value of those rewards. We also found that the connectivity from dlPFC BA-46 to a region of ventromedial prefrontal cortex (vmPFC) widely associated with the computation of stimulus values, increased at the time of choice, and especially during trials in which subjects chose delayed rewards. Finally, we found that estimates of effective connectivity between these two regions played a critical role in predicting out-of-sample, between-subject differences in discount rates. Together with previous findings in dietary choice, these results suggest that a common set of computational and neurobiological mechanisms facilitate choices in favor of long-term reward in both settings.

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Additional Information:© 2014 Hare, Hakimi and Rangel. Received: 15 December 2013; Accepted: 25 February 2014; Published online: 18 March 2014. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. This article was submitted to Decision Neuroscience, a section of the journal Frontiers in Neuroscience. Conflict of Interest Statement: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The authors wish to thank Oscar Bartra, Joseph McGuire, Joseph Kable, and John Clithero for sharing data used to create portions of Figures 2–4. This work was supported by the National Science Foundation grant 0851408 to Antonio Rangel and Todd A. Hare.
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Subject Keywords:fMRI, temporal discounting, vmPFC, DLPFC, effective connectivity, individual differences, delay of gratification
Record Number:CaltechAUTHORS:20140407-134053962
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Official Citation: Hare TA, Hakimi S and Rangel A (2014) Activity in dlPFC and its effective connectivity to vmPFC are associated with temporal discounting. Front. Neurosci. 8:50.
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:44707
Deposited By: David McCaslin
Deposited On:07 Apr 2014 21:35
Last Modified:10 Nov 2021 16:55

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