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Constancy and trade-offs in the neuroanatomical and metabolic design of the cerebral cortex

Karbowski, Jan (2014) Constancy and trade-offs in the neuroanatomical and metabolic design of the cerebral cortex. Frontiers in Neural Circuits, 8 . Art. No. 9. ISSN 1662-5110. doi:10.3389/fncir.2014.00009.

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Mammalian brains span about four orders of magnitude in cortical volume and have to operate in different environments that require diverse behavioral skills. Despite these geometric and behavioral diversities, the examination of cerebral cortex across species reveals that it contains a substantial number of conserved characteristics that are associated with neuroanatomy and metabolism, i.e., with neuronal connectivity and function. Some of these cortical constants or invariants have been known for a long time but not sufficiently appreciated, and others were only recently discovered. The focus of this review is to present the cortical invariants and discuss their role in the efficient information processing. Global conservation in neuroanatomy and metabolism, as well as their correlated regional and developmental variability suggest that these two parallel systems are mutually coupled. It is argued that energetic constraint on cortical organization can be strong if cerebral blood supplied is either below or above a certain level, and it is rather soft otherwise. Moreover, because maximization or minimization of parameters associated with cortical connectivity, function and cost often leads to conflicts in design, it is argued that the architecture of the cerebral cortex is a result of structural and functional compromises.

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Additional Information:© 2014 Karbowski. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. Received: 11 July 2013; Accepted: 23 January 2014; Published online: 11 February 2014. The work was supported by the grant from the Polish Ministry of Science and Education (NN 518 409238), and partly by the Marie Curie Actions EU grant FP7-PEOPLE-2007-IRG-210538.
Funding AgencyGrant Number
Polish Ministry of Science and EducationNN 518 409238
Marie Curie Actions EU grantFP7-PEOPLE-2007-IRG-210538
Subject Keywords:cerebral cortex; conservation; connectivity; metabolism; capillary; constraints; allometry; evolutionary design
Record Number:CaltechAUTHORS:20140410-091257124
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Official Citation:Karbowski J (2014) Constancy and trade-offs in the neuroanatomical and metabolic design of the cerebral cortex. Front. Neural Circuits 8:9. doi: 10.3389/fncir. 2014.00009
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:44845
Deposited By: Jason Perez
Deposited On:10 Apr 2014 16:55
Last Modified:10 Nov 2021 16:57

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