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Oral [^(13)C]bicarbonate measurement of CO_2 stores and dynamics in children and adults

Armon, Yaacov and Cooper, Dan M. and Springer, Chaim and Barstow, Thomas J. and Rahimizadeh, Hooman and Landaw, Elliot and Epstein, Sam (1990) Oral [^(13)C]bicarbonate measurement of CO_2 stores and dynamics in children and adults. Journal of Applied Physiology, 69 (5). pp. 1754-1760. ISSN 8750-7587.

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During exercise, less additional CO_2 is stored per kilogram body weight in children than in adults, suggesting that children have a smaller capacity to store metabolically produced CO_2. To examine this, tracer doses of [^(13)C]bicarbonate were administered orally to 10 children (8-12 yr) and 12 adults (25-40 yr) at rest. Washout of ^(13)CO_2 in breath was analyzed to estimate recovery of tracer, mean residence time (MRT), and size of CO_2 stores. CO_2 production (VCO_2) was also measured breath by breath using gas exchange techniques. Recovery did not differ significantly between children [73 ± 13% (SD)] and adults (71 ± 9%). MRT was shorter in children (42 ± 7 min) compared with adults (66 ± 15 min, P < 0.001). VCO_2 per kilogram was higher in the children (5.4 ± 0.9 ml.min^(-1).kg^(-1)) compared with adults (3.1 ± 0.5, P less than 0.0001). Tracer estimate of CO_2 production was correlated to VCO_2 (r = 0.86, P < 0.0001) and when corrected for mean recovery accurately predicted the VCO_2 to within 3 ± 14%. There was no difference in the estimate of resting CO_2 stores between children (222 ± 52 ml CO_2/kg) and adults (203 ± 42 ml CO_2/kg). We conclude that orally administered [^(13)C]bicarbonate can be used to assess CO_2 transport dynamics. The data do not support the hypothesis of lower CO_2 stores under resting conditions in children.

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Additional Information:© 1990 American Physiological Society. This information is current as of May 15, 2013. Received 20 November 1989; accepted in final form 9 July 1990. This work was supported by National Heart, Lung, and Blood Institute Research Grant HL-11907. Y. Armon is the recipient of a research fellowship of the Joseph Drown Foundation. D. M. Cooper is a recipient of the Career Investigator Award of the American Lung Association. E. Landaw is supported in part by National Cancer Institute Research Grant CA-16042.
Funding AgencyGrant Number
National Heart, Lung, and Blood Institute Research GrantHL-11907
Joseph Drown Foundation research fellowshipUNSPECIFIED
American Lung Association Career Investigator AwardUNSPECIFIED
National Cancer Institute Research GrantCA-16042
Subject Keywords:carbon dioxide transport; stable isotope; carbon dioxide production; growth; development
Issue or Number:5
Record Number:CaltechAUTHORS:20140414-144818973
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Official Citation: Oral [13C]bicarbonate measurement of CO2 stores and dynamics in children and adults Y. Armon, D. M. Cooper, C. Springer, T. J. Barstow, H. Rahimizadeh, E. Landaw, S. Epstein Journal of Applied Physiology Nov 1990,69(5)1754-1760
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:44936
Deposited By: Ruth Sustaita
Deposited On:14 Apr 2014 22:36
Last Modified:03 Oct 2019 06:24

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