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Gastrointestinal Issues in Autism Spectrum Disorder

Hsiao, Elaine Y. (2014) Gastrointestinal Issues in Autism Spectrum Disorder. Harvard Review of Psychiatry, 22 (2). pp. 104-111. ISSN 1067-3229. doi:10.1097/HRP.0000000000000029.

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While autism spectrum disorder (ASD) is characterized by communication impairments, social abnormalities, and stereotypic behaviors, several medical comorbidities are observed in autistic individuals. Of these, gastrointestinal (GI) abnormalities are of particular interest given their reported prevalence and correlation with the severity of core autism-related behavioral abnormalities. This review discusses the GI pathologies seen in ASD individuals and the association of particular GI conditions with known genetic and environmental risk factors for autism. It further addresses how GI abnormalities can affect the neuropathological and behavioral features of ASD, as well as the development of autism-related endophenotypes such as immune dysregulation, hyperserotonemia, and metabolic dysfunction. Finally, it presents emerging evidence for a gut-brain connection in autism, wherein GI dysfunction may contribute to the pathogenesis or severity of ASD symptoms.

Item Type:Article
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Hsiao, Elaine Y.0000-0002-1633-588X
Additional Information:© 2014 President and Fellows of Harvard College. Original manuscript received 16 February 2013, accepted for publication subject to revision 8 April 2013; revised manuscript received 15 May 2013. Declaration of interest: The author reports no conflicts of interest. The author alone is responsible for the content and writing of the article.
Subject Keywords:gastroenterology, gut, immunity, intestine, neurodevelopment
Issue or Number:2
Record Number:CaltechAUTHORS:20140421-091942025
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Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:45061
Deposited By: Tony Diaz
Deposited On:21 Apr 2014 22:14
Last Modified:10 Nov 2021 16:59

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