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The Role of Organic Peroxides in the Induction of Mutations

Dickey, Frank H. and Cleland, George H. and Lotz, Carol (1949) The Role of Organic Peroxides in the Induction of Mutations. Proceedings of the National Academy of Sciences of the United States of America, 35 (10). pp. 581-586. ISSN 0027-8424.

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The discovery by Wyss, Stone, and Clark' that bacteria grown on a substrate recently exposed to ultra-violet light are subject to high mutation rates shows clearly that some meta-stable chemical substance, probably of no great complexity, is an intermediate in at least a part of the mutagenic action of ultra-violet light. It was supposed that hydrogen peroxide might be responsible for these results, but subsequent work has shown that this cannot be the whole explanation. [2] However, organic peroxides are known to be formed by the action of ultra-violet light on many compounds and such peroxides might very well be the intermediate agents producing the substrate irradiation effect.

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Additional Information:Copyright © 1949 by the National Academy of Sciences Communicated by G. W. Beadle, August 15, 1949 This investigation was supported in part by a research grant from Merck and Co. [F.H.D. was a] DuPont Predoctoral Fellow in Chemistry 1948-1949. The authors wish to thank Professor Norman H. Horowitz for valuable assistance and advice.
Issue or Number:10
Record Number:CaltechAUTHORS:DICpnas49b
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Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:4527
Deposited By: Archive Administrator
Deposited On:27 Aug 2006
Last Modified:02 Oct 2019 23:13

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