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Clonal analyses in the anterior pre-placodal region: implications for the early lineage bias of placodal progenitors

Bhattacharyya, Sujata and Bronner, Marianne E. (2013) Clonal analyses in the anterior pre-placodal region: implications for the early lineage bias of placodal progenitors. International Journal of Developmental Biology, 57 (9-10). pp. 753-757. ISSN 0214-6282. PMCID PMC4041203. https://resolver.caltech.edu/CaltechAUTHORS:20140501-111631382

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Abstract

Cranial ectodermal placodes, a vertebrate innovation, contribute to the adenohypophysis and peripheral nervous system of the head, including the paired sense organs (eyes, nose, ears) and sensory ganglia of the Vth, VIIth, IXth and Xth cranial nerves. Fate-maps of groups of cells in amphibians, teleosts and amniotes have demonstrated that all placodes have a common origin in a horseshoe shaped territory, known as the preplacodal region (PPR), which surrounds the presumptive neural plate of the late gastrula/early neurula stage embryo. Given the extensive regional overlap of progenitors for different placodes in the chick embryo, it has been a matter of debate as to whether individual cells in the PPR are truly multipotent progenitors, with regard to placodal identity, or rather are lineage-biased or restricted to a specific placodal type prior to overt differentiation. Utilizing clonal analyses in vivo, we demonstrate here that the anterior PPR comprises some precursors that contribute either to the olfactory or lens placode well before they are spatially segregated or committed to either of these placodal fates. This suggests that lineage bias towards a specific placodal fate may coincide with induction of the PPR.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1387/ijdb.130155mb DOIArticle
http://www.ijdb.ehu.es/web/paper.php?doi=130155mbPublisherArticle
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4041203PubMed CentralArticle
ORCID:
AuthorORCID
Bronner, Marianne E.0000-0003-4274-1862
Additional Information:© 2013 UBC Press. Accepted: 3 July 2013. Final, author-corrected PDF published online: 4 December 2013. We are extremely grateful to Dr. Scott E. Fraser for lending his expertise in teaching SB the technique of intracellular injections. We would also like to thank Drs. Tatiana Hochgreb and Marcos Simões-Costa for their insightful comments and helpful discussions. This work was supported by R01 DE16459 to MEB.
Funders:
Funding AgencyGrant Number
NIHR01 DE16459
Subject Keywords:placode; olfactory; lens; pre-placodal region; lineage
Issue or Number:9-10
PubMed Central ID:PMC4041203
Record Number:CaltechAUTHORS:20140501-111631382
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20140501-111631382
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:45419
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:01 May 2014 21:32
Last Modified:03 Oct 2019 06:30

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