CaltechAUTHORS
  A Caltech Library Service

Alcohol Reduces Cross-Frequency Theta-Phase Gamma-Amplitude Coupling in Resting Electroencephalography

Lee, Jaewon and Yun, Kyongsik (2014) Alcohol Reduces Cross-Frequency Theta-Phase Gamma-Amplitude Coupling in Resting Electroencephalography. Alcoholism: Clinical and Experimental Research, 38 (3). pp. 770-776. ISSN 0145-6008. http://resolver.caltech.edu/CaltechAUTHORS:20140501-142542411

Full text is not posted in this repository. Consult Related URLs below.

Use this Persistent URL to link to this item: http://resolver.caltech.edu/CaltechAUTHORS:20140501-142542411

Abstract

Background: The electrophysiological inhibitory mechanism of cognitive control for alcohol remains largely unknown. The purpose of the study was to compare electroencephalogram (EEG) power spectra and cross-frequency phase–amplitude coupling (CFPAC) at rest and during a simple subtraction task after acute alcohol ingestion. Methods: Twenty-one healthy subjects participated in this study. Two experiments were performed 1 week apart, and the order of the experiments was randomly assigned to each subject. During the experiments, each subject was provided with orange juice containing alcohol or orange juice only. We recorded EEG activity and analyzed power spectra and CFPAC data. Results: The results showed prominent theta-phase gamma-amplitude coupling at the frontal and parietal electrodes at rest. This effect was significantly reduced after alcohol ingestion. Conclusions: Our findings suggest that theta-phase gamma-amplitude coupling is deficiently synchronized at rest after alcohol ingestion. Therefore, cross-frequency coupling could be a useful tool for studying the effects of alcohol on the brain and investigating alcohol addiction.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1111/acer.12310DOIArticle
http://onlinelibrary.wiley.com/doi/10.1111/acer.12310/abstractPublisherArticle
Additional Information:© Research Society on Alcoholism. Received for publication March 14, 2013; accepted September 20, 2013. The authors thank Sujin Kim, So Yul Kim, Yul Mai Song, and Young Sung Kim (Neuropsychiatry Research Laboratory, Gongju National Hospital, South Korea) for their valuable help for this study. This work was supported by Sinhye Choi Research Fund (2011) of Korean Neuropsychiatric Association.
Funders:
Funding AgencyGrant Number
Sinhye Choi Research Fund (2011) of Korean Neuropsychiatric AssociationUNSPECIFIED
Subject Keywords:Cross-Frequency Phase–Amplitude Coupling; Theta-Phase Gamma-Amplitude Coupling, Alcohol; Electroencephalography; Inhibitory Effect
Record Number:CaltechAUTHORS:20140501-142542411
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:20140501-142542411
Official Citation:Lee, J. and Yun, K. (2014), Alcohol Reduces Cross-Frequency Theta-Phase Gamma-Amplitude Coupling in Resting Electroencephalography. Alcoholism: Clinical and Experimental Research, 38: 770–776. doi: 10.1111/acer.12310
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:45440
Collection:CaltechAUTHORS
Deposited By: Jason Perez
Deposited On:01 May 2014 22:47
Last Modified:04 Jun 2015 20:30

Repository Staff Only: item control page