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Brush-first and Click: Efficient Synthesis of Nanoparticles that Degrade and Release Doxorubicin in Response to Light

Burts, Alan O. and Liao, Longyan and Lu, Ying Y. and Tirrell, David A. and Johnson, Jeremiah A. (2014) Brush-first and Click: Efficient Synthesis of Nanoparticles that Degrade and Release Doxorubicin in Response to Light. Photochemistry and Photobiology, 90 (2). pp. 380-385. ISSN 0031-8655. http://resolver.caltech.edu/CaltechAUTHORS:20140509-095521349

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Abstract

New strategies for the synthesis of multifunctional particles that respond to external stimuli and release biologically relevant agents will enable the discovery of new formulations for drug delivery. In this article, we combine two powerful methods: brush-first ring-opening metathesis polymerization and copper-catalyzed azide–alkyne cycloaddition click chemistry, for the synthesis of a novel class of brush-arm star polymers (BASPs) that simultaneously degrade and release the anticancer drug doxorubicin (DOX) in response to 365 nm light. In vitro cell viability studies were performed to study the toxicity of azide- and DOX-loaded BASPs. The former were completely nontoxic. The latter showed minimal toxicity in the absence of light; UV-triggered DOX release led to IC_(50) values that were similar to that of free DOX.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1111/php.12182 DOIArticle
http://onlinelibrary.wiley.com/doi/10.1111/php.12182/abstractPublisherArticle
ORCID:
AuthorORCID
Tirrell, David A.0000-0003-3175-4596
Additional Information:© 2013 The American Society of Photobiology. Received 14 August 2013, accepted 30 September 2013. Article first published online: 25 Nov. 2013. This work has been supported in part by the MIT Department of Chemistry, the MIT Research Support Committee, and the MIT Lincoln Laboratories Advanced Concepts Committee.
Funders:
Funding AgencyGrant Number
MIT Department of ChemistryUNSPECIFIED
MIT Research Support CommitteeUNSPECIFIED
MIT Lincoln Laboratories Advanced Concepts CommitteeUNSPECIFIED
Record Number:CaltechAUTHORS:20140509-095521349
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:20140509-095521349
Official Citation:Burts, A. O., Liao, L., Lu, Y. Y., Tirrell, D. A. and Johnson, J. A. (2014), Brush-first and Click: Efficient Synthesis of Nanoparticles that Degrade and Release Doxorubicin in Response to Light. Photochemistry and Photobiology, 90: 380–385. doi: 10.1111/php.12182
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:45637
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:09 May 2014 17:06
Last Modified:25 Feb 2015 23:21

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