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Myotypic Respecification of Regenerated Nerve-fibres in Cichlid Fishes

Arora, H. L. and Sperry, R. W. (1957) Myotypic Respecification of Regenerated Nerve-fibres in Cichlid Fishes. Journal of Embryology and Experimental Morphology, 5 (3). pp. 256-263. ISSN 0022-0752. http://resolver.caltech.edu/CaltechAUTHORS:20140514-143251140

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Abstract

In man and other mammals normal motor co-ordination is not restored, as a rule, after regeneration of a severed peripheral nerve-trunk (Sperry, 1945). The random misdirection of regenerating fibres into foreign muscles tends to prevent normal dissociated action within the re-innervated musculature. In contrast, larval amphibians have been found to show excellent recovery of motor function in the form of ‘homologous or myotypic response’ (Weiss, 1936, 1941) following the cutting and regeneration of limb-nerves, limb transplantation, and the cross-connecting of limb nerves to foreign muscles. Similarly, good restoration of muscle co-ordination has been observed in the pectoral fin of adult teleost fishes (Sperry, 1950, 1956).


Item Type:Article
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http://dev.biologists.org/content/5/3/256.abstractPublisherArticle
Additional Information:© 1957 Company of Biologists. Received September 18, 1956. This investigation was supported by the F. P. Hixon Fund of the California Institute of Technology and a grant from Eli Lilly and Company.
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Caltech F. P. Hixon FundUNSPECIFIED
Eli Lilly and Company grantUNSPECIFIED
Record Number:CaltechAUTHORS:20140514-143251140
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:20140514-143251140
Official Citation: H. L. Arora and R. W. Sperry Myotypic Respecification of Regenerated Nerve-fibres in Cichlid Fishes J Embryol Exp Morphol September 1957 5:256-263
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:45749
Collection:CaltechAUTHORS
Deposited By: Ruth Sustaita
Deposited On:14 May 2014 21:52
Last Modified:14 May 2014 21:52

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