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Model for estimating the penetration depth limit of the time-reversed ultrasonically encoded optical focusing technique

Jang, Mooseok and Ruan, Haowen and Judkewitz, Benjamin and Yang, Changhuei (2014) Model for estimating the penetration depth limit of the time-reversed ultrasonically encoded optical focusing technique. Optics Express, 22 (5). pp. 5787-5807. ISSN 1094-4087. PMCID PMC4086332. https://resolver.caltech.edu/CaltechAUTHORS:20140516-083523368

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Abstract

The time-reversed ultrasonically encoded (TRUE) optical focusing technique is a method that is capable of focusing light deep within a scattering medium. This theoretical study aims to explore the depth limits of the TRUE technique for biological tissues in the context of two primary constraints – the safety limit of the incident light fluence and a limited TRUE’s recording time (assumed to be 1 ms), as dynamic scatterer movements in a living sample can break the time-reversal scattering symmetry. Our numerical simulation indicates that TRUE has the potential to render an optical focus with a peak-to-background ratio of ~2 at a depth of ~103 mm at wavelength of 800 nm in a phantom with tissue scattering characteristics. This study sheds light on the allocation of photon budget in each step of the TRUE technique, the impact of low signal on the phase measurement error, and the eventual impact of the phase measurement error on the strength of the TRUE optical focus.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1364/OE.22.005787 DOIArticle
http://www.opticsinfobase.org/oe/abstract.cfm?uri=oe-22-5-5787PublisherArticle
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4086332/PubMed CentralArticle
ORCID:
AuthorORCID
Yang, Changhuei0000-0001-8791-0354
Additional Information:© 2014 Optical Society of America. Received 8 Jan 2014; revised 27 Feb 2014; accepted 27 Feb 2014; published 5 Mar 2014. We thank Mr. Roarke Horstmeyer for helpful discussions. This work is supported by NIH 1DP2OD007307-01. Benjamin Judkewitz is recipient of a Sir Henry Wellcome Fellowship from the Wellcome Trust.
Funders:
Funding AgencyGrant Number
NIH1DP2OD007307-01
Wellcome TrustUNSPECIFIED
Sir Henry Wellcome FellowshipUNSPECIFIED
Issue or Number:5
Classification Code:(070.5040) Phase conjugation; (090.1995) Digital holography; (090.2880) Holographic interferometry; (110.7050) Turbid media; (170.7170) Ultrasound; (220.1080) Active or adaptive optics
PubMed Central ID:PMC4086332
Record Number:CaltechAUTHORS:20140516-083523368
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20140516-083523368
Official Citation:M. Jang, H. Ruan, B. Judkewitz, and C. Yang, "Model for estimating the penetration depth limit of the time-reversed ultrasonically encoded optical focusing technique," Opt. Express 22, 5787-5807 (2014)
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:45786
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:16 May 2014 19:53
Last Modified:09 Mar 2020 13:19

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