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Prokaryotic Argonautes defend genomes against invasive DNA

Hur, Junho K. and Olovnikov, Ivan and Aravin, Alexei A. (2014) Prokaryotic Argonautes defend genomes against invasive DNA. Trends in Biochemical Sciences, 39 (6). pp. 257-259. ISSN 0968-0004. PMCID PMC4041519.

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Argonaute proteins are central players in small RNAmediated silencing mechanisms such as RNA interference (RNAi), microRNA repression and piRNA-mediated transposon silencing. In eukaryotes, Argonautes bind small RNAs that guide them to RNA targets in order to regulate gene expression and repress invasive genomic elements. Although Argonaute proteins are conserved in all life forms from bacteria to eukaryotes, until now studies have focused on the biological functions of eukaryotic Argonautes. Here we highlight two recent studies that discover the functions of prokaryotic Argonautes in defence against exogenous DNA.

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Additional Information:© 2014 Elsevier Ltd. Available online 13 May 2014. We thank members of the Aravin lab for discussion and Alexandre Webster for critical reading of the manuscript. Research in Aravin lab is supported by grants from the National Institutes of Health (HD057233, GM097363, and OD007371A) and by the Searle Scholar and the Packard Fellowship Awards.
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Searle Scholar AwardUNSPECIFIED
Packard Fellowship AwardUNSPECIFIED
Issue or Number:6
PubMed Central ID:PMC4041519
Record Number:CaltechAUTHORS:20140521-090032542
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Official Citation:Junho K. Hur, Ivan Olovnikov, Alexei A. Aravin, Prokaryotic Argonautes defend genomes against invasive DNA, Trends in Biochemical Sciences, Volume 39, Issue 6, June 2014, Pages 257-259, ISSN 0968-0004, (
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:45862
Deposited By: Jason Perez
Deposited On:27 May 2014 17:37
Last Modified:03 Oct 2019 06:37

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