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A high-efficiency microfluidic device for size-selective trapping and sorting

Kim, Jinho and Erath, Jessey and Rodriguez, Ana and Yang, Changhuei (2014) A high-efficiency microfluidic device for size-selective trapping and sorting. Lab on a Chip, 14 (14). pp. 2480-2490. ISSN 1473-0197. PMCID PMC4073585. https://resolver.caltech.edu/CaltechAUTHORS:20140527-110620702

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Abstract

We report the development of a simple poly(dimethylsiloxane) microfluidic device for high-efficiency trapping and sorting of micron-size particles. In this device, hydrodynamic fluid flow through the sieve-like microfluidic channel sequentially fills the trap positions with particles of the trap size, and particles smaller than the trap size pass through the sieve and are trapped by smaller traps downstream. By incorporating side channels alongside the main channel, we were able to decouple the fluidic flow in one stage from the flows in the other stages. This decoupling allows us to modularize each stage of the device regardless of the size of the entire device. In our demonstration experiment with the prototype, we showed that more than 85% of the polystyrene microspheres (of sizes 15 μm, 6 μm and 4 μm) were sorted in the correct segment of the device that targets their respective sizes. Moreover, this high-efficiency device was able to trap all microspheres which were introduced into the device. Finally, we tested the device's ability to trap and sort three different species of waterborne parasites (Entamoeba, Giardia, and Cryptosporidium) and obtained excellent sorting performance.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1039/C4LC00219A DOIArticle
http://pubs.rsc.org/en/Content/ArticleLanding/2014/LC/c4lc00219aPublisherArticle
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4073585/PubMed CentralArticle
ORCID:
AuthorORCID
Yang, Changhuei0000-0001-8791-0354
Additional Information:© 2014 Royal Society of Chemistry. Received 20th February 2014; accepted 7th May 2014. First published online 7 May 2014. We would like to thank Seung Ah Lee for helpful advice on micro-fabrication. This project was funded by the National Institute of Health (NIH) Agency Award 1R01AI096226-01. Jinho Kim's work was supported by the Kwanjeong Educational Foundation.
Funders:
Funding AgencyGrant Number
NIH1R01AI096226-01
Kwanjeong Educational FoundationUNSPECIFIED
Issue or Number:14
PubMed Central ID:PMC4073585
Record Number:CaltechAUTHORS:20140527-110620702
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20140527-110620702
Official Citation:A high-efficiency microfluidic device for size-selective trapping and sorting Jinho Kim, Jessey Erath, Ana Rodriguez and Changhuei Yang Lab Chip, 2014, 14, 2480-2490 DOI: 10.1039/C4LC00219A
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:45919
Collection:CaltechAUTHORS
Deposited By: Jason Perez
Deposited On:27 May 2014 19:05
Last Modified:09 Mar 2020 13:19

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