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Inferring eye position from populations of lateral intraparietal neurons

Graf, Arnulf B. A. and Andersen, Richard A. (2014) Inferring eye position from populations of lateral intraparietal neurons. eLife, 3 . Art. No. e02813. ISSN 2050-084X. PMCID PMC4021542. doi:10.7554/eLife.02813.

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Understanding how the brain computes eye position is essential to unraveling high-level visual functions such as eye movement planning, coordinate transformations and stability of spatial awareness. The lateral intraparietal area (LIP) is essential for this process. However, despite decades of research, its contribution to the eye position signal remains controversial. LIP neurons have recently been reported to inaccurately represent eye position during a saccadic eye movement, and to be too slow to support a role in high-level visual functions. We addressed this issue by predicting eye position and saccade direction from the responses of populations of LIP neurons. We found that both signals were accurately predicted before, during and after a saccade. Also, the dynamics of these signals support their contribution to visual functions. These findings provide a principled understanding of the coding of information in populations of neurons within an important node of the cortical network for visual-motor behaviors.

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Andersen, Richard A.0000-0002-7947-0472
Additional Information:© 2014 Graf and Andersen. This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited. Received March 16, 2014. Accepted April 11, 2014. Published May 20, 2014. We are grateful to M Yanike for insightful comments on the manuscript. We thank K Pejsa for animal care, and V Shcherbatyuk and T Yao for technical and administrative assistance. Author contributions: ABAG designed the research, collected the data, created the models, analyzed the data, and wrote the paper. RAA designed the research and wrote the paper. The authors declare that no competing interests exist. Funding: National Institutes of Health EY005522, EY013337, EY007492, The Boswell Foundation. The funders had no role in study design, data collection and interpretation, or the decision to submit the work for publication. Ethics: Animal experimentation: All procedures were in accordance with the guidelines of the Caltech Institutional Animal Care and Use Committee (protocol 1256) and the National Institute of Health Guide for the Care and Use of Laboratory Animals.
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James G. Boswell FoundationUNSPECIFIED
PubMed Central ID:PMC4021542
Record Number:CaltechAUTHORS:20140604-205544451
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Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:46084
Deposited By: George Porter
Deposited On:05 Jun 2014 15:22
Last Modified:10 Nov 2021 17:20

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