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Fidelity of Cotranslational Protein Targeting by the Signal Recognition Particle

Zhang, Xin and Shan, Shu-ou (2014) Fidelity of Cotranslational Protein Targeting by the Signal Recognition Particle. Annual Review of Biophysics, 43 . pp. 381-408. ISSN 1936-122X. PMCID PMC4444370. http://resolver.caltech.edu/CaltechAUTHORS:20140605-104144841

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Abstract

Accurate folding, assembly, localization, and maturation of newly synthesized proteins are essential to all cells and require high fidelity in the protein biogenesis machineries that mediate these processes. Here, we review our current understanding of how high fidelity is achieved in one of these processes, the cotranslational targeting of nascent membrane and secretory proteins by the signal recognition particle (SRP). Recent biochemical, biophysical, and structural studies have elucidated how the correct substrates drive a series of elaborate conformational rearrangements in the SRP and SRP receptor GTPases; these rearrangements provide effective fidelity checkpoints to reject incorrect substrates and enhance the fidelity of this essential cellular pathway. The mechanisms used by SRP to ensure fidelity share important conceptual analogies with those used by cellular machineries involved in DNA replication, transcription, and translation, and these mechanisms likely represent general principles for other complex cellular pathways.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1146/annurev-biophys-051013-022653DOIArticle
http://www.annualreviews.org/doi/abs/10.1146/annurev-biophys-051013-022653PublisherArticle
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4444370/PubMed CentralArticle
ORCID:
AuthorORCID
Shan, Shu-ou0000-0002-6526-1733
Additional Information:© 2014 Annual Reviews. The authors are not aware of any affiliations, memberships, funding, or financial holdings that might be perceived as affecting the objectivity of this review.
Subject Keywords:protein biogenesis, signal sequence, GTPases, RNA, ribosome, protein translocation
PubMed Central ID:PMC4444370
Record Number:CaltechAUTHORS:20140605-104144841
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:20140605-104144841
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:46097
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:05 Jun 2014 18:15
Last Modified:20 Jul 2017 23:52

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