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Distinguishing informational from value-related encoding of rewarding and punishing outcomes in the human brain

Jessup, Ryan K. and O'Doherty, John P. (2014) Distinguishing informational from value-related encoding of rewarding and punishing outcomes in the human brain. European Journal of Neuroscience, 39 (11). pp. 2014-2026. ISSN 0953-816X. PMCID PMC5551688. http://resolver.caltech.edu/CaltechAUTHORS:20140605-152254603

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Abstract

There is accumulating evidence implicating a set of key brain regions in encoding rewarding and punishing outcomes, including the orbitofrontal cortex, medial prefrontal cortex, ventral striatum, anterior insula, and anterior cingulate. However, it has proved challenging to reach consensus concerning the extent to which different brain areas are involved in differentially encoding rewarding and punishing outcomes. Here, we show that many of the brain areas involved in outcome processing represent multiple outcome components: encoding the value of outcomes (whether rewarding or punishing) and informational coding, i.e. signaling whether a given outcome is rewarding or punishing, ignoring magnitude or experienced utility. In particular, we report informational signals in the lateral orbitofrontal cortex and anterior insular cortex that respond to both rewarding and punishing feedback, even though value-related signals in these areas appear to be selectively driven by punishing feedback. These findings highlight the importance of taking into account features of outcomes other than value when characterising the contributions of different brain regions in outcome processing.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1111/ejn.12625DOIArticle
http://onlinelibrary.wiley.com/doi/10.1111/ejn.12625/abstractPublisherArticle
http://onlinelibrary.wiley.com/doi/10.1111/ejn.12625/suppinfoPublisherSupporting Information
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5551688PubMed CentralArticle
Additional Information:© 2014 Federation of European Neuroscience Societies and John Wiley & Sons Ltd. Article first published online: 24 May 2014. This work was funded by the Science Foundation Ireland (grant 08/IN.1/ B1844) and a grant from the Gordon and Betty Moore Foundation to J.P.O’D. We thank Teresa Furey, Simon Dunne, and Sojo Josephs for their help with participant recruitment and data collection.
Funders:
Funding AgencyGrant Number
Science Foundation, Ireland08/IN.1/B1844
Gordon and Betty Moore FoundationUNSPECIFIED
Subject Keywords:decision making, insula cortex, orbitofrontal cortex, outcome coding, ventral striatum
PubMed Central ID:PMC5551688
Record Number:CaltechAUTHORS:20140605-152254603
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:20140605-152254603
Official Citation:Jessup, R. K. and O'Doherty, J. P. (2014), Distinguishing informational from value-related encoding of rewarding and punishing outcomes in the human brain. European Journal of Neuroscience, 39: 2014–2026. doi: 10.1111/ejn.12625
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:46109
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:05 Jun 2014 22:30
Last Modified:14 Aug 2017 22:09

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