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Recording chronically from the same neurons in awake, behaving primates

Tolias, Andreas S. and Ecker, Alexander S. and Siapas, Athanassios G. and Hoenselaar, Andreas and Keliris, Georgios A. and Logothetis, Nikos K. (2007) Recording chronically from the same neurons in awake, behaving primates. Journal of Neurophysiology, 98 (6). pp. 3780-3790. ISSN 0022-3077. https://resolver.caltech.edu/CaltechAUTHORS:20140610-153359849

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Abstract

Understanding the mechanisms of learning requires characterizing how the response properties of individual neurons and interactions across populations of neurons change over time. To study learning in vivo, we need the ability to track an electrophysiological signature that uniquely identifies each recorded neuron for extended periods of time. We have identified such an extracellular signature using a statistical framework that allows quantification of the accuracy by which stable neurons can be identified across successive recording sessions. Our statistical framework uses spike waveform information recorded on a tetrode's four channels to define a measure of similarity between neurons recorded across time. We use this framework to quantitatively demonstrate for the first time the ability to record from the same neurons across multiple consecutive days and weeks. The chronic recording techniques and methods of analyses we report can be used to characterize the changes in brain circuits due to learning.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1152/jn.00260.2007 DOIArticle
http://jn.physiology.org/content/98/6/3780PublisherArticle
ORCID:
AuthorORCID
Siapas, Athanassios G.0000-0001-8837-678X
Additional Information:© 2007 The American Physiological Society. Submitted 7 March 2007; accepted in final form 15 October 2007. First published October 17, 2007. We thank P. Berens, D. Görür, A. Gretton, and S. Smirnakis for useful discussions. Grants: This work was supported by the Max Planck Society and by a National Eye Institute National Research Service Award to A. S. Tolias. The costs of publication of this article were defrayed in part by the payment of page charges. The article must therefore be hereby marked “advertisement” in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.
Funders:
Funding AgencyGrant Number
Max Planck SocietyUNSPECIFIED
National Eye Institute National Research Service AwardUNSPECIFIED
Issue or Number:6
Record Number:CaltechAUTHORS:20140610-153359849
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20140610-153359849
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:46188
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:10 Jun 2014 23:20
Last Modified:09 Mar 2020 13:19

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