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Effects of consistency vs. variability in robotically controlled training of stepping in adult spinal mice

Cai, L. L. and Fong, A. J. and Otoshi, C. K. and Liang, Y. Q. and Cham, J. G. and Zhong, H. and Roy, R. R. and Edgerton, V. R. and Burdick, J. W. (2005) Effects of consistency vs. variability in robotically controlled training of stepping in adult spinal mice. In: Proceedings of the 2005 IEEE 9th International Conference on Rehabilitation Robotics. IEEE , Piscataway, NJ, pp. 575-579.

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This paper studies the possible benefit that can be obtained by introducing variability into the robotic control of trajectories used to train hindlimb locomotion in adult spinal mice. The spinal cords of adult female Swiss-Webster mice were completely transected at a mid-thoracic level. Fourteen days post-transection, the spinal mice were robotically trained to step in the presence of a 5-HT agonist, quipazine, for a period of six weeks. In this pilot study nine animals were divided into three groups, each receiving a different control strategy: a fixed training trajectory (Group A), a variable training trajectory without interlimb coordination imposed (Group B) and a variable training trajectory with hindlimb bilateral coordination imposed (Group C). Preliminary results indicate that Group A recovers more slowly than the two groups receiving variable modes of robotic training. Groups B and C show higher levels of recovery than Group A in terms of the number of steps performed during testing sessions, as well as in their step periodicity and shape consistency. Group C displays a higher incidence of alternating stepping than Group B. These results indicate that variable trajectory robotic training paradigms may be more effective than fixed trajectory paradigms in promoting robust post-injury stepping behavior. Furthermore, it appears that the inclusion of interlimb coordination is an important contribution to successful training.

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Additional Information:© 2005 IEEE. This work is supported by the Christopher Reeve Paralysis Foundation (#VEC 2002-2) and the National Institutes of Health (1 R01 HD044830-01).
Funding AgencyGrant Number
Christopher Reeve Paralysis FoundationVEC 2002-2
NIH1 R01 HD044830-01
Record Number:CaltechAUTHORS:20140611-081051132
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Official Citation:Cai, L.L.; Fong, A.J.; Otoshi, C.K.; Liang, Y.Q.; Cham, J.G.; Zhong, H.; Roy, R.R.; Edgerton, V.R.; Burdick, J.W., "Effects of consistency vs. variability in robotically controlled training of stepping in adult spinal mice," Rehabilitation Robotics, 2005. ICORR 2005. 9th International Conference on , vol., no., pp.575,579, 28 June-1 July 2005 doi: 10.1109/ICORR.2005.1502028 URL:
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:46193
Deposited By: Tony Diaz
Deposited On:11 Jun 2014 16:32
Last Modified:10 Nov 2021 17:22

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