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Maternal and Fetal Factors that Contribute to the Localization of T Regulatory Cells During Pregnancy

Wambach, Carrie M. and Patel, Sonal N. and Kahn, Daniel A. (2014) Maternal and Fetal Factors that Contribute to the Localization of T Regulatory Cells During Pregnancy. American Journal of Reproductive Immunology, 71 (5). pp. 391-400. ISSN 1046-7408. PMCID PMC4007192.

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Problem: To determine the interplay between fetal antigenicity and local maternal factors in determining reproductive tract T regulatory (Treg) cell accumulation during pregnancy. Method of study: Examination of maternal Treg composition in the uterus, cervix, and uteroplacental interface (UPI) of murine syngeneic and allogeneic pregnancies and non-pregnant controls by flow cytometry. The impact of fetal antigenicity was defined by either fetal gender in syngeneic pregnancies or by allogeneic paternity. Impact of IL-6 on local Treg composition was determined using syngeneic pregnancies in IL-6^(−/−) females. Results: An increased fraction of CD4^+ T cells in the pregnant uterine lymphocytic infiltrate and draining pelvic lymph nodes are Tregs. Maternal IL-6 decreases Treg accumulation within the uterus and to a greater extent in the cervix in syngeneic pregnancy. Fetal antigenicity is matched by accumulation of Tregs to the UPI. Treg accumulation at the UPI of non-antigenic female fetuses is determined by the intrauterine position relative to male siblings. Conclusion: Reproductive tract tissue Treg composition during pregnancy is influenced by maternal IL-6 and fetal antigenicity.

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Additional Information:© 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd. Submission December 9, 2013; accepted February 5, 2014. Article first published online: 14 Mar. 2014. The authors wish to acknowledge the support of Harvey L. Karp Discovery Award, a gift from the Scholars in Translational Medicine Program, the California Institute of Technology – University of California, Los Angeles Joint Center for Translational Medicine, and the Reproductive Scientist Development Program NIH/NICHD 2K12HD000849-26 (Moley).
Funding AgencyGrant Number
Harvey L. Karp Discovery AwardUNSPECIFIED
Scholars in Translational Medicine ProgramUNSPECIFIED
Caltech-UCLA Joint Center for Translational MedicineUNSPECIFIED
NIH/NICHD Reproductive Scientist Development Program2K12HD000849-26
Subject Keywords:Allogeneic; cervix; interleukin-6; T regulatory; uteroplacental interface
Issue or Number:5
PubMed Central ID:PMC4007192
Record Number:CaltechAUTHORS:20140619-125638776
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Official Citation:Wambach CM, Patel SN, Kahn DA. Maternal and fetal factors that contribute to the localization of T regulatory cells during pregnancy. Am J Reprod Immunol 2014; 71: 391–400
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:46362
Deposited By: Tony Diaz
Deposited On:19 Jun 2014 21:50
Last Modified:03 Oct 2019 06:43

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