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Differential Effects of Neurokinin-1 Receptor Activation in Subregions of the Periaqueductal Gray Matter on Conditional and Unconditional Fear Behaviors in Rats

Mongeau, Raymond and De Oca, Beatrice M. and Fanselow, Michael S. and Marsden, Charles A. (1998) Differential Effects of Neurokinin-1 Receptor Activation in Subregions of the Periaqueductal Gray Matter on Conditional and Unconditional Fear Behaviors in Rats. Behavioral Neuroscience, 112 (5). pp. 1125-1135. ISSN 0735-7044. https://resolver.caltech.edu/CaltechAUTHORS:20140625-143317559

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Abstract

Central neurokinin-1 (NK-1) receptors are thought to modulate aversion, whereas the periaqueductal gray matter (PAG) is a common pathway for the integration of fear behaviors. The authors determined whether injection of an NK-1 agonist (GR73632) into subregions of the PAG would alter fear-related behaviors. Behavioral inactivity was increased by GR73632 injected into the caudodorsal PAG or the dorsal raphe. Flight behavior induced by stimulation of the dorsal PAG or by a footshock was decreased after injection of GR73632 into the dorsal PAG. Rats that had 6 pairings of a tone with a footshock after injection of GR73632 into the dorsal PAG displayed more freezing behavior than controls at the beginning of the session. However, there was no change in the shock- or the tone-induced freezing because some GR73632-treated rats, but no controls, froze during the baseline period. It is concluded that NK-1 receptors in the dorsal PAG modulate the unconditional but not the mnemonic aspects of fear behaviors.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://psycnet.apa.org/journals/bne/112/5/1125.html#articleAbstract_d1e196PublisherArticle
http://dx.doi.org/10.1037/0735-7044.112.5.1125DOIArticle
ORCID:
AuthorORCID
Fanselow, Michael S.0000-0002-3850-5966
Additional Information:© 1998 American Psychological Association. Received October 31, 1997. Revision received March 6, 1998. Accepted April 23, 1998. Research at Nottingham University was supported by a fellowship from the Human Frontier Science Program, and research at UCLA was supported by National Science Foundation Grant IBN-9723295. We would like to thank Glaxo Research and Development, Stevenage, England, for their gift of the NK-1 antagonist GR203040.
Funders:
Funding AgencyGrant Number
Human Frontier Science ProgramUNSPECIFIED
NSFIBN-9723295
Glaxo Research and Development, Stevenage, EnglandGR203040
Issue or Number:5
Record Number:CaltechAUTHORS:20140625-143317559
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20140625-143317559
Official Citation:Mongeau, R., De Oca, B. M., Fanselow, M. S., & Marsden, C. A. (1998). Differential effects of neurokinin-1 receptor activation in subregions of the periaqueductal gray matter on conditional and unconditional fear behaviors in rats. Behavioral Neuroscience, 112(5), 1125-1135. doi:10.1037/0735-7044.112.5.1125
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:46513
Collection:CaltechAUTHORS
Deposited By: Ruth Sustaita
Deposited On:25 Jun 2014 22:37
Last Modified:09 Mar 2020 13:18

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