Mongeau, Raymond and De Oca, Beatrice M. and Fanselow, Michael S. and Marsden, Charles A. (1998) Differential Effects of Neurokinin-1 Receptor Activation in Subregions of the Periaqueductal Gray Matter on Conditional and Unconditional Fear Behaviors in Rats. Behavioral Neuroscience, 112 (5). pp. 1125-1135. ISSN 0735-7044. https://resolver.caltech.edu/CaltechAUTHORS:20140625-143317559
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Abstract
Central neurokinin-1 (NK-1) receptors are thought to modulate aversion, whereas the periaqueductal gray matter (PAG) is a common pathway for the integration of fear behaviors. The authors determined whether injection of an NK-1 agonist (GR73632) into subregions of the PAG would alter fear-related behaviors. Behavioral inactivity was increased by GR73632 injected into the caudodorsal PAG or the dorsal raphe. Flight behavior induced by stimulation of the dorsal PAG or by a footshock was decreased after injection of GR73632 into the dorsal PAG. Rats that had 6 pairings of a tone with a footshock after injection of GR73632 into the dorsal PAG displayed more freezing behavior than controls at the beginning of the session. However, there was no change in the shock- or the tone-induced freezing because some GR73632-treated rats, but no controls, froze during the baseline period. It is concluded that NK-1 receptors in the dorsal PAG modulate the unconditional but not the mnemonic aspects of fear behaviors.
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| Additional Information: | © 1998 American Psychological Association. Received October 31, 1997. Revision received March 6, 1998. Accepted April 23, 1998. Research at Nottingham University was supported by a fellowship from the Human Frontier Science Program, and research at UCLA was supported by National Science Foundation Grant IBN-9723295. We would like to thank Glaxo Research and Development, Stevenage, England, for their gift of the NK-1 antagonist GR203040. | |||||||||
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| Issue or Number: | 5 | |||||||||
| Record Number: | CaltechAUTHORS:20140625-143317559 | |||||||||
| Persistent URL: | https://resolver.caltech.edu/CaltechAUTHORS:20140625-143317559 | |||||||||
| Official Citation: | Mongeau, R., De Oca, B. M., Fanselow, M. S., & Marsden, C. A. (1998). Differential effects of neurokinin-1 receptor activation in subregions of the periaqueductal gray matter on conditional and unconditional fear behaviors in rats. Behavioral Neuroscience, 112(5), 1125-1135. doi:10.1037/0735-7044.112.5.1125 | |||||||||
| Usage Policy: | No commercial reproduction, distribution, display or performance rights in this work are provided. | |||||||||
| ID Code: | 46513 | |||||||||
| Collection: | CaltechAUTHORS | |||||||||
| Deposited By: | Ruth Sustaita | |||||||||
| Deposited On: | 25 Jun 2014 22:37 | |||||||||
| Last Modified: | 09 Mar 2020 13:18 |
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