Marotta, Christopher and Lester, Henry A. and Dougherty, Dennis A. (2014) Identifying Motifs Essential for Selective Activation of Nicotinic Acetylcholine Receptors. Biophysical Journal, 106 (2). 341A. ISSN 0006-3495. https://resolver.caltech.edu/CaltechAUTHORS:20140710-092155936
Full text is not posted in this repository. Consult Related URLs below.
Use this Persistent URL to link to this item: https://resolver.caltech.edu/CaltechAUTHORS:20140710-092155936
Abstract
Neuronal Nicotinic acetylcholine receptors (nAChRs) are found throughout the brain and have vital roles in memory and learning. In addition, these ligand gated ion channel are major targets of drug research for neurological disorders. Here, the two stoichiometries of α4β2 nAChRs expressed in Xenopus oocytes were probed using two agonists that display stoichiometry selectivity: Sazetidine A and NS9283. The results from these studies led to the following conclusions that may be generalized to the nAChR family: 1) an agonist must be bound to each α subunit in the receptor in order to fully activate the receptor and 2) three key residues located on the complementary side of the subunit dictate agonist selectivity. Through better understanding of agonist binding, more potent and selective responses with minimized off target responses can be obtained.
Item Type: | Article | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Related URLs: |
| ||||||||||||
ORCID: |
| ||||||||||||
Additional Information: | © 2014 Biophysical Society. Published by Elsevier Inc. | ||||||||||||
Issue or Number: | 2 | ||||||||||||
Record Number: | CaltechAUTHORS:20140710-092155936 | ||||||||||||
Persistent URL: | https://resolver.caltech.edu/CaltechAUTHORS:20140710-092155936 | ||||||||||||
Official Citation: | Christopher Marotta, Henry A. Lester, Dennis A. Dougherty, Identifying Motifs Essential for Selective Activation of Nicotinic Acetylcholine Receptors, Biophysical Journal, Volume 106, Issue 2, Supplement 1, 28 January 2014, Page 341a, ISSN 0006-3495, http://dx.doi.org/10.1016/j.bpj.2013.11.1951. (http://www.sciencedirect.com/science/article/pii/S0006349513032098) | ||||||||||||
Usage Policy: | No commercial reproduction, distribution, display or performance rights in this work are provided. | ||||||||||||
ID Code: | 47127 | ||||||||||||
Collection: | CaltechAUTHORS | ||||||||||||
Deposited By: | Tony Diaz | ||||||||||||
Deposited On: | 10 Jul 2014 19:37 | ||||||||||||
Last Modified: | 03 Oct 2019 06:50 |
Repository Staff Only: item control page