CaltechAUTHORS
  A Caltech Library Service

Down-regulation of pancreatic and duodenal homeobox-1 by somatostatin receptor subtype 5: a novel mechanism for inhibition of cellular proliferation and insulin secretion by somatostatin

Zhou, Guisheng and Sinnett-Smith, Jim and Liu, Shi-He and Yu, Juehua and Wu, James and Sanchez, Robbi and Pandol, Stephen J. and Abrol, Ravinder and Nemunaitis, John and Rozengurt, Enrique and Brunicardi, F. Charles (2014) Down-regulation of pancreatic and duodenal homeobox-1 by somatostatin receptor subtype 5: a novel mechanism for inhibition of cellular proliferation and insulin secretion by somatostatin. Frontiers in Physiology, 5 . Art. No. 226. ISSN 1664-042X. PMCID PMC4069483. doi:10.3389/fphys.2014.00226. https://resolver.caltech.edu/CaltechAUTHORS:20140714-154111231

[img]
Preview
PDF - Published Version
Creative Commons Attribution.

524kB

Use this Persistent URL to link to this item: https://resolver.caltech.edu/CaltechAUTHORS:20140714-154111231

Abstract

Somatostatin (SST) is a regulatory peptide and acts as an endogenous inhibitory regulator of the secretory and proliferative responses of target cells. SST's actions are mediated by a family of seven transmembrane domain G protein-coupled receptors that comprise five distinct subtypes (SSTR1-5). SSTR5 is one of the major SSTRs in the islets of Langerhans. Homeodomain-containing transcription factor pancreatic and duodenal homeobox-1 (PDX-1) is essential for pancreatic development, β cell differentiation, maintenance of normal β cell functions in adults and tumorigenesis. Recent studies show that SSTR5 acts as a negative regulator for PDX-1 expression and that SSTR5 mediates somatostatin's inhibitory effect on cell proliferation and insulin expression/excretion through down-regulating PDX-1 expression. SSTR5 exerts its inhibitory effect on PDX-1 expression at both the transcriptional level by down-regulating PDX-1 mRNA and the post-translational level by enhancing PDX-1 ubiquitination. Identification of PDX-1 as a transcriptional target for SSTR5 may help in guiding the choice of therapeutic cancer treatments.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://journal.frontiersin.org/Journal/10.3389/fphys.2014.00226/abstractPublisherArticle
http://dx.doi.org/10.3389/fphys.2014.00226DOIArticle
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4069483/PubMed CentralArticle
ORCID:
AuthorORCID
Abrol, Ravinder0000-0001-7333-6793
Additional Information:© 2014 Zhou, Sinnett-Smith, Liu, Yu, Wu, Sanchez, Pandol, Abrol, Nemunaitis, Rozengurt and Brunicardi. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. Received: 25 April 2014; Accepted: 31 May 2014; Published online: 25 June 2014. This work was supported by The Pilot and Feasibility Study Grant from the CURE: Digestive Disease Research Center (P30DK41301) (to Guisheng Zhou) and the National Institutes of Health (NIH) grants NIDDK R01-DK46441 and NCI R01-CA095731 and Ann and Jerry Moss Foundation (to F. Charles Brunicardi). Gratitude is extended to Katie Elsbury for her editorial assistance and Priscilla Massey and Jacqueline Ismen for their administrative assistance. Conflict of Interest Statement: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Funders:
Funding AgencyGrant Number
CURE Digestive Disease Research CenterP30DK41301
NIHNIDDK R01-DK46441
NIHNCI R01-CA095731
Ann and Jerry Moss FoundationUNSPECIFIED
Subject Keywords:G protein-coupled receptors, pancreatic and duodenal homeobox-1, single nucleotide polymorphisms, somatostatin, somatostatin receptor
PubMed Central ID:PMC4069483
DOI:10.3389/fphys.2014.00226
Record Number:CaltechAUTHORS:20140714-154111231
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20140714-154111231
Official Citation:Zhou G, Sinnett-Smith J, Liu S-H, Yu J, Wu J, Sanchez R, Pandol SJ, Abrol R, Nemunaitis J, Rozengurt E and Brunicardi FC (2014) Down-regulation of pancreatic and duodenal homeobox-1 by somatostatin receptor subtype 5: a novel mechanism for inhibition of cellular proliferation and insulin secretion by somatostatin. Front. Physiol. 5:226. doi: 10.3389/fphys.2014.00226
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:47192
Collection:CaltechAUTHORS
Deposited By: Ruth Sustaita
Deposited On:15 Jul 2014 15:44
Last Modified:10 Nov 2021 17:36

Repository Staff Only: item control page