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Comparative Analysis of Homo sapiens and Mus musculus Cyclin-Dependent Kinase (CDK) Inhibitor Genes P16 (MTSl) and PIS (MTS2)

Jiang, Ping and Stone, Steven and Wagner, Roger and Wang, Susan L. and Dayananth, Priya and Kozak, Christine A. and Wold, Barbara J. and Kamb, Alexander (1995) Comparative Analysis of Homo sapiens and Mus musculus Cyclin-Dependent Kinase (CDK) Inhibitor Genes P16 (MTSl) and PIS (MTS2). Journal of Molecular Evolution, 41 (6). pp. 795-802. ISSN 0022-2844. doi:10.1007/BF00173159. https://resolver.caltech.edu/CaltechAUTHORS:20140716-084520222

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Abstract

Cyclin-dependent kinase inhibitors are a growing family of molecules that regulate important transitions in the cell cycle. At least one of these molecules, p16, has been implicated in human tumorigenesis while its close homolog, p15, is induced by cell contact and transforming growth factor-β (TGF-β). To investigate the evolutionary and functional features of p15 and p16, we have isolated mouse (Mus musculus) homologs of each gene. Comparative analysis of these sequences provides evidence that the genes have similar functions in mouse and human. In addition, the comparison suggests that a gene conversion event is part of the evolution of the human p15 and p16 genes.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1007/BF00173159DOIArticle
http://link.springer.com/article/10.1007/BF00173159PublisherArticle
ORCID:
AuthorORCID
Wold, Barbara J.0000-0003-3235-8130
Additional Information:© 1995 Springer-Verlag New York, Inc. Received: 30 June 1995; Accepted: 27 July 1995.
Subject Keywords:P16; P15; MTS1; MTS2; CDK inhibitor; Gene conversion; Mouse; Human
Issue or Number:6
DOI:10.1007/BF00173159
Record Number:CaltechAUTHORS:20140716-084520222
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20140716-084520222
Official Citation:Jiang, P., Stone, S., Wagner, R., Wang, S., Dayananth, P., Kozak, C., . . . Kamb, A. (1995). Comparative analysis of Homo sapiens and Mus musculus cyclin-dependent kinase (CDK) inhibitor genes P16 (MTS1) and P15 (MTS2). Journal of Molecular Evolution, 41(6), 795-802. doi: 10.1007/bf00173159
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:47255
Collection:CaltechAUTHORS
Deposited By: Jason Perez
Deposited On:16 Jul 2014 23:24
Last Modified:10 Nov 2021 17:37

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