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Comparative Analysis of Homo sapiens and Mus musculus Cyclin-Dependent Kinase (CDK) Inhibitor Genes P16 (MTSl) and PIS (MTS2)

Jiang, Ping and Stone, Steven and Wagner, Roger and Wang, Susan L. and Dayananth, Priya and Kozak, Christine A. and Wold, Barbara J. and Kamb, Alexander (1995) Comparative Analysis of Homo sapiens and Mus musculus Cyclin-Dependent Kinase (CDK) Inhibitor Genes P16 (MTSl) and PIS (MTS2). Journal of Molecular Evolution, 41 (6). pp. 795-802. ISSN 0022-2844. doi:10.1007/BF00173159.

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Cyclin-dependent kinase inhibitors are a growing family of molecules that regulate important transitions in the cell cycle. At least one of these molecules, p16, has been implicated in human tumorigenesis while its close homolog, p15, is induced by cell contact and transforming growth factor-β (TGF-β). To investigate the evolutionary and functional features of p15 and p16, we have isolated mouse (Mus musculus) homologs of each gene. Comparative analysis of these sequences provides evidence that the genes have similar functions in mouse and human. In addition, the comparison suggests that a gene conversion event is part of the evolution of the human p15 and p16 genes.

Item Type:Article
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Wold, Barbara J.0000-0003-3235-8130
Additional Information:© 1995 Springer-Verlag New York, Inc. Received: 30 June 1995; Accepted: 27 July 1995.
Subject Keywords:P16; P15; MTS1; MTS2; CDK inhibitor; Gene conversion; Mouse; Human
Issue or Number:6
Record Number:CaltechAUTHORS:20140716-084520222
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Official Citation:Jiang, P., Stone, S., Wagner, R., Wang, S., Dayananth, P., Kozak, C., . . . Kamb, A. (1995). Comparative analysis of Homo sapiens and Mus musculus cyclin-dependent kinase (CDK) inhibitor genes P16 (MTS1) and P15 (MTS2). Journal of Molecular Evolution, 41(6), 795-802. doi: 10.1007/bf00173159
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:47255
Deposited On:16 Jul 2014 23:24
Last Modified:10 Nov 2021 17:37

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