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How Proteolysis Drives the Cell Cycle

King, Randall W. and Deshaies, Raymond J. and Peters, Jan-Michael and Kirschner, Marc W. (1996) How Proteolysis Drives the Cell Cycle. Science, 274 (5293). pp. 1652-1659. ISSN 0036-8075. https://resolver.caltech.edu/CaltechAUTHORS:20140722-085457381

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Abstract

Oscillations in the activity of cyclin-dependent kinases (CDKs) promote progression through the eukaryotic cell cycle. This review examines how proteolysis regulates CDK activity—by degrading CDK activators or inhibitors—and also how proteolysis may directly trigger the transition from metaphase to anaphase. Proteolysis during the cell cycle is mediated by two distinct ubiquitin-conjugation pathways. One pathway, requiring CDC34, initiates DNA replication by degrading a CDK inhibitor. The second pathway, involving a large protein complex called the anaphase-promoting complex or cyclosome, initiates chromosome segregation and exit from mitosis by degrading anaphase inhibitors and mitotic cyclins. Proteolysis therefore drives cell cycle progression not only by regulating CDK activity, but by directly influencing chromosome and spindle dynamics.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1126/science.274.5293.1652 DOIArticle
http://www.sciencemag.org/content/274/5293/1652PublisherArticle
http://www.jstor.org/stable/2890936JSTORArticle
ORCID:
AuthorORCID
Deshaies, Raymond J.0000-0002-3671-9354
Additional Information:© 1996 American Association for the Advancement of Science. We thank K. Nasmyth and K. Lustig for comments on the manuscript and M. Hochstrasser, V. Chau, A. Varshavsky, M. Mendenhall, E. Schwob, M. Goebl, D. Mathog, and D. Pellman for sharing results prior to publication.
Issue or Number:5293
Record Number:CaltechAUTHORS:20140722-085457381
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20140722-085457381
Official Citation:How Proteolysis Drives the Cell Cycle Randall W. King, Raymond J. Deshaies, Jan-Michael Peters and Marc W. Kirschner Science, New Series, Vol. 274, No. 5293 (Dec. 6, 1996), pp. 1652-1659 Published by: American Association for the Advancement of Science Article Stable URL: http://www.jstor.org/stable/2890936
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:47385
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:22 Jul 2014 16:07
Last Modified:03 Oct 2019 06:53

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