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Molecular Characterization of Shaker, a Drosophila Gene That Encodes a Potassium Channel

Kamb, Alexander and Iverson, Linda E. and Tanouye, Mark A. (1987) Molecular Characterization of Shaker, a Drosophila Gene That Encodes a Potassium Channel. Cell, 50 (3). pp. 405-413. ISSN 0092-8674. https://resolver.caltech.edu/CaltechAUTHORS:20140722-104348012

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Abstract

The Drosophila Shaker (Sh) gene appears to encode a type of voltage-sensitive potassium (K+) channel called the A channel. We have isolated Sh as part of a 350 kb chromosomal walk. The region around Sh contains four identified transcription units. We find that Sh corresponds to a very large transcription unit encompassing a total of about 95 kb of genomic DNA and split by a major 85 kb intron. Sh has multiple hydrophobic domains that have a high probability of being membrane-spanning, consistent with the proposal that it encodes an ion channel.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1016/0092-8674(87)90494-6DOIArticle
http://www.sciencedirect.com/science/article/pii/0092867487904946PublisherArticle
Additional Information:© 1987 Cell Press. Received June 18, 1987. A. L. and L. I. contributed equally to the work presented here. We thank D. Ballinger, U. Banerjee, M. Gautam, J. Pollock, M. Ramaswami, J. Tseng-Crank, and K. VijayRaghavan for comments. This research was supported by the Pfeiffer Research Foundation and USPHS grant NS21327-01 to M. T. L. I. was supported by a Muscular Dystrophy Association Fellowship and the E. S. Gosney Fund. A. K. was supported by NRSA training grant GM07616. M. T. is a McKnight Foundation Scholar and a Sloan Foundation Fellow. The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked “advertisement” in accordance with 18 USC. Section 1734 solely to indicate this fact.
Funders:
Funding AgencyGrant Number
Pfeiffer Research FoundationUNSPECIFIED
USPHSNS21327-01
Muscular Dystrophy Association FellowshipUNSPECIFIED
E. S. Gosney FundUNSPECIFIED
NIHGM07616
McKnight FoundationUNSPECIFIED
Alfred P. Sloan FoundationUNSPECIFIED
Issue or Number:3
Record Number:CaltechAUTHORS:20140722-104348012
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20140722-104348012
Official Citation:Kamb, A., Iverson, L. E., & Tanouye, M. A. (1987). Molecular characterization of Shaker, a Drosophila gene that encodes a potassium channel. Cell, 50(3), 405-413. doi: http://dx.doi.org/10.1016/0092-8674(87)90494-6
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:47391
Collection:CaltechAUTHORS
Deposited By: Jason Perez
Deposited On:22 Jul 2014 22:48
Last Modified:03 Oct 2019 06:53

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