Kamb, Alexander and Iverson, Linda E. and Tanouye, Mark A. (1987) Molecular Characterization of Shaker, a Drosophila Gene That Encodes a Potassium Channel. Cell, 50 (3). pp. 405-413. ISSN 0092-8674. doi:10.1016/0092-8674(87)90494-6. https://resolver.caltech.edu/CaltechAUTHORS:20140722-104348012
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Abstract
The Drosophila Shaker (Sh) gene appears to encode a type of voltage-sensitive potassium (K+) channel called the A channel. We have isolated Sh as part of a 350 kb chromosomal walk. The region around Sh contains four identified transcription units. We find that Sh corresponds to a very large transcription unit encompassing a total of about 95 kb of genomic DNA and split by a major 85 kb intron. Sh has multiple hydrophobic domains that have a high probability of being membrane-spanning, consistent with the proposal that it encodes an ion channel.
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| Additional Information: | © 1987 Cell Press. Received June 18, 1987. A. L. and L. I. contributed equally to the work presented here. We thank D. Ballinger, U. Banerjee, M. Gautam, J. Pollock, M. Ramaswami, J. Tseng-Crank, and K. VijayRaghavan for comments. This research was supported by the Pfeiffer Research Foundation and USPHS grant NS21327-01 to M. T. L. I. was supported by a Muscular Dystrophy Association Fellowship and the E. S. Gosney Fund. A. K. was supported by NRSA training grant GM07616. M. T. is a McKnight Foundation Scholar and a Sloan Foundation Fellow. The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked “advertisement” in accordance with 18 USC. Section 1734 solely to indicate this fact. | ||||||||||||||||
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| Issue or Number: | 3 | ||||||||||||||||
| DOI: | 10.1016/0092-8674(87)90494-6 | ||||||||||||||||
| Record Number: | CaltechAUTHORS:20140722-104348012 | ||||||||||||||||
| Persistent URL: | https://resolver.caltech.edu/CaltechAUTHORS:20140722-104348012 | ||||||||||||||||
| Official Citation: | Kamb, A., Iverson, L. E., & Tanouye, M. A. (1987). Molecular characterization of Shaker, a Drosophila gene that encodes a potassium channel. Cell, 50(3), 405-413. doi: http://dx.doi.org/10.1016/0092-8674(87)90494-6 | ||||||||||||||||
| Usage Policy: | No commercial reproduction, distribution, display or performance rights in this work are provided. | ||||||||||||||||
| ID Code: | 47391 | ||||||||||||||||
| Collection: | CaltechAUTHORS | ||||||||||||||||
| Deposited By: | INVALID USER | ||||||||||||||||
| Deposited On: | 22 Jul 2014 22:48 | ||||||||||||||||
| Last Modified: | 10 Nov 2021 17:39 |
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