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Spatial Expression of the Alternatively Spliced EIIIB and EIIIA Segments of Fibronectin in the Early Chicken Embryo

Peters, John and Sechrist, Jack and Luetolf, Simone and Loredo, Grace and Bronner-Fraser, Marianne (2002) Spatial Expression of the Alternatively Spliced EIIIB and EIIIA Segments of Fibronectin in the Early Chicken Embryo. Cell Communication and Adhesion, 9 (4). pp. 221-238. ISSN 1541-9061. doi:10.1080/15419060216015. https://resolver.caltech.edu/CaltechAUTHORS:20140723-083018918

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Abstract

Using domain-specific antibodies, we have analyzed the tissue distribution of fibronectins (FNs) containing the alternatively spliced EIIIB and EIIIA segments relative to total FN in early chicken embryos. The results show a selective loss of EIIIA+ FN staining in the notochordal sheath and in cartilaginous structures between 4.5 and 7.0 days of development. In other regions, EIIIB+ and EIIIA+ FNs are extensively codistributed in and around mesoderm-derived structures (somites, notochord, heart, and blood vessels), in basal laminae of endoderm and ectoderm-derived structures, as well as within the vicinity of neural crest formation and migration. We also noted that EIIIA staining overlaps with spatial patterns of distribution that have previously been described for the α4 integrin subunit, a component of the EIIIA receptor α4β1.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1080/15419060216015DOIArticle
ORCID:
AuthorORCID
Bronner-Fraser, Marianne0000-0003-4274-1862
Additional Information:© 2002 Taylor and Francis. Received 29 July 2002; accepted 26 November 2002. JHP was supported by a UCLA Claude Pepper Older Americans Independence Center, NIA #P60 AG10415, a gift from the Charles B. See Foundation, as well as Career Development Award and Merit Review Grants, both from the Department of Veterans Affairs. MBF was supported by USPHS HD15527. We wish to thank Richard Hynes for generous gifts of antibodies.
Funders:
Funding AgencyGrant Number
UCLA Claude Pepper Older Americans Independence CenterUNSPECIFIED
NIHP60 AG10415
Charles B. See FoundationUNSPECIFIED
Department of Veterans AffairsUNSPECIFIED
U.S. Public Health Service (USPHS)HD15527
Subject Keywords:alternative splicing; chicken embryo; development; extracellular matrix; fibronectin; neural crest
Issue or Number:4
DOI:10.1080/15419060216015
Record Number:CaltechAUTHORS:20140723-083018918
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20140723-083018918
Official Citation:Spatial Expression of the Alternatively Spliced EIIIB and EIIIA Segments of Fibronectin in the Early Chicken Embryo John Peters, Jack Sechrist, Simone Luetolf, Grace Loredo, Marianne Bronner-Fraser Cell Communication and Adhesion 2002 9:4, 221-238 Read More: http://informahealthcare.com/action/showCitFormats?doi=10.1080%2F15419060216015
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:47414
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:23 Jul 2014 15:45
Last Modified:10 Nov 2021 17:39

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