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A Drosophila Mutant with a Temperature-Sensitive Block in Nerve Conduction

Wu, Chun-Fang and Ganetzky, Barry and Jan, Lily Yeh and Jan, Yuh-Nung and Benzer, Seymour (1978) A Drosophila Mutant with a Temperature-Sensitive Block in Nerve Conduction. Proceedings of the National Academy of Sciences of the United States of America, 75 (8). pp. 4047-4051. ISSN 0027-8424. PMCID PMC392928.

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A mutant, napts (no action potential, temperature-sensitive), is described in which axonal conduction fails at high temperature. Synaptic transmission at the larval neuromuscular junction is unimpaired. Larvae and adults are rapidly paralyzed at restrictive temperatures; they recover rapidly when the temperature is decreased. The mutant gene is recessive and is located on the second chromosome at map position 56.

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Additional Information:© 1978 National Academy of Sciences. Contributed by Seymour Benzer, May 26, 1978. We thank our colleagues for constant comment, particularly Lawrence Kauvar and Duncan Byers. This work was supported by National Science Foundation Grant PCM73-01972. C-F.W., B.G., Y-N.J., and L.Y.J. held fellowships from, respectively, the Spencer, Jane Coffin Childs, and Muscular Dystrophy Foundations and the National Institutes of Health.
Funding AgencyGrant Number
Spencer FoundationUNSPECIFIED
Jane Coffin Childs FoundationUNSPECIFIED
Muscular Dystrophy FoundationUNSPECIFIED
Subject Keywords:neurogenetics; paralysis; action potential
Issue or Number:8
PubMed Central ID:PMC392928
Record Number:CaltechAUTHORS:WUCpnas78
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Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:4747
Deposited By: Archive Administrator
Deposited On:05 Sep 2006
Last Modified:02 Oct 2019 23:15

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