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Abnormal Neural Activation to Faces in the Parents of Children with Autism

Yucel, G. H. and Belger, A. and Bizzell, J. and Parlier, M. and Adolphs, R. and Piven, J. (2015) Abnormal Neural Activation to Faces in the Parents of Children with Autism. Cerebral Cortex, 25 (12). pp. 4653-4666. ISSN 1047–3211. PMCID PMC4635912. https://resolver.caltech.edu/CaltechAUTHORS:20140728-161809608

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Abstract

Parents of children with an autism spectrum disorder (ASD) show subtle deficits in aspects of social behavior and face processing, which resemble those seen in ASD, referred to as the “Broad Autism Phenotype ” (BAP). While abnormal activation in ASD has been reported in several brain structures linked to social cognition, little is known regarding patterns in the BAP. We compared autism parents with control parents with no family history of ASD using 2 well-validated face-processing tasks. Results indicated increased activation in the autism parents to faces in the amygdala (AMY) and the fusiform gyrus (FG), 2 core face-processing regions. Exploratory analyses revealed hyper-activation of lateral occipital cortex (LOC) bilaterally and right FG in autism parents with aloof personality (“BAP+”) and autism parents without the aloof personality (“BAP−”). Findings suggest that abnormalities of the AMY and FG are related to underlying genetic liability for ASD, whereas abnormalities in the LOC and right FG are more specific to behavioral features of the BAP. Results extend our knowledge of neural circuitry underlying abnormal face processing beyond those previously reported in ASD to individuals with shared genetic liability for autism and a subset of genetically related individuals with the BAP.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1093/cercor/bhu147DOIArticle
http://cercor.oxfordjournals.org/content/25/12/4653PublisherArticle
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4635912/PubMed CentralArticle
ORCID:
AuthorORCID
Adolphs, R.0000-0002-8053-9692
Additional Information:© The Author 2014. Cerebral Cortex Advance Access published July 23, 2014. First published online: July 23, 2014. This work was supported by grants from the National Institutes of Health (MH077843 and P30HD0003110) to JP. The authors wish to thank Ashley Stevens, Elisabeth Tyroler, Deanna Tracy, Meghan Vanasek, and Scott Wallace for recruitment of all subjects, Michael Casp, Zoe Englander, and Mary Agnes McMahon for assistance in data collection, and all the families who participated in this study.
Funders:
Funding AgencyGrant Number
NIHMH077843
NIHP30HD0003110
National Institute of Mental Health (NIMH)UNSPECIFIED
Subject Keywords:amygdala, autism, broad autism phenotype, face perception, fusiform gyrus
Issue or Number:12
PubMed Central ID:PMC4635912
Record Number:CaltechAUTHORS:20140728-161809608
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20140728-161809608
Official Citation:G. H. Yucel, A. Belger, J. Bizzell, M. Parlier, R. Adolphs, and J. Piven Abnormal Neural Activation to Faces in the Parents of Children with Autism Cereb. Cortex (2015) 25 (12): 4653-4666 first published online July 23, 2014 doi:10.1093/cercor/bhu147
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:47539
Collection:CaltechAUTHORS
Deposited By: Joanne McCole
Deposited On:29 Jul 2014 19:26
Last Modified:03 Oct 2019 06:54

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